哮喘和慢性阻塞性肺疾病患者血清肿瘤坏死因子α和白细胞介素6的变化

Tumor necrosis factor-α and interleukin-6 in patients with asthma or chronic obstructive pulmonary disease.

目的 探讨血清肿瘤坏死因子α(TNF α)和白细胞介素 6 (IL 6 )在哮喘中的作用。方法 设立正常对照组、哮喘组和慢性阻塞性肺疾病 (COPD)组 ,检测 3组患者血清中TNF α和IL 6的含量。结果 3组的TNF α(pg/ml)和IL 6 (pg/ml)测定结果分别为 :正常对照组 2 .6 18± 0 .92 1,2 7.6 5 3± 19.939;哮喘组2 1.2 86± 12 .4 16 ,937.4 97± 170 .732 ;COPD组 2 0 .5 2 4± 10 .35 4 ,975 .0 35± 2 5 3.913。哮喘组和COPD组血清中TNF α和IL 6的含量明显高于正常对照组 (P <0 .0 1) ,组内TNF α和IL 6的含量呈正相关 ;哮喘组与COPD组比较TNF α和IL 6均无显著差异 (P >0 .0 5 )。结论 TNF α和IL 6参与哮喘和COPD的气道炎症 。

Objective To investigate the role of tumor necrosis factor α (TNF α) and Interleukin 6(IL 6) on asthma.Methods The TNF α and IL 6 levels in normal control,asthma and COPD groups were measured respectively.Results The TNF α and IL 6 levels in the three groups were as follows:2.618±0.921 and 27.653±19.939 in normal control,21.286±12.416 and 937.497±170.732 in asthma group and 20.524±10.354 and 975.035±253.913 in COPD group.TNF α and IL 6 levels in asthma group and COPD group were remarkably higher than those in normal control group(P<0.01) and there was positive correlation in the same group but there was no significant difference in TNF α and IL 6 levels between asthma and COPD group(P>0.05).Conclusion TNF α and IL 6 are involved in the airway inflammation in asthma and COPD patients,which may take great part in asthma complicated with obstructive emphysema.