兔运动区致痫灶周围皮质软膜下环切对痫性放电及功能影响的实验研究

A experimental study of the influence of the subpial circumcision on motor cortex round the epileptogenic focus to the epileptic discharge and motorsensory unctions in the rabbit

针对重要功能区皮质致痫灶设计了一种新术式——致痫灶周围皮质软膜下环切术。手术切断致痫灶周围皮质表层的水平纤维连结,而保留皮质的垂直柱状纤维。其目的在于阻断痫性放电,从而控制发作,减轻脑功能损害。本组用家兔25只,分三组进行,用青霉素G钠10.00U在运动区皮质产生局灶性癫痫模型。通过对照组,致痫灶切除组,软膜下环切组,说明软膜下环切术在阻断痫性放电的产生和传播方面能达到致痫灶切除术的同样效果。

It aims at the epileptogenic focus in the important functional area,anthors designs a new approach to the surgical treatment-subpial circumcision of the motor cortex round the epileptogenicfocus. In the operation,surgeons circumcise round the epileptogenic focus the horizontal fibrous connections in the superficial layer of cerebral eortex,but retaining the vertical columniform fibers, thus the seizure could be controlled,meanwhile the damage of the cerebral functions would be diminished.In this experimental study,let 25 rabbits divide themselves into 3 groups:multiple subpial circumcision;excision of epileptogenic focus:and group of contrast. The models of experimental focal epilepsy are produced by topically applied 10,000 U. of penicillin G sodium to the cerebral cortex of the rabbits. The results shows in respect of impeding the production and transmission of the epileptic discharge,the method of multiple subpial circumcision of cortex could get the same effects as good as that of excision of the epileptogenic focus.