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缺氧诱导因子与肿瘤血管生成 被引量:21

Hypoxia-inducible Factors in tumor angiogenesis
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摘要 缺氧诱导因子 (HIF)是一类重要的缺氧应答调控因子 ,在部分肿瘤组织中表达明显增高 ,与肿瘤血管生成密切相关。研究认为肿瘤细胞表型变化或缺氧环境可能导致HIF活性增加 ,进而通过依赖或非依赖血管内皮生长因子 (VEGF)途径促进肿瘤血管的生成。对HIF调控肿瘤血管生成机制的进一步研究 。
作者 朱宏 施瑞华
出处 《国外医学(肿瘤学分册)》 2004年第8期591-594,共4页 Foreign Medical Sciences (Cancer Section)
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