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B细胞性血液肿瘤的多药耐药逆转

Multi-drug resistance in B cell of hematologicalm alignancies and its reversal
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摘要 B淋巴细胞的增殖与分化异常与急慢性淋巴细胞性白血病及淋巴瘤等血液系统恶性肿瘤密切相关 ,目前该类疾病主要治疗措施之一是化疗 ,但B细胞对化疗药物产生多药耐药 (MDR)已成为限制疗效的关键因素。近年研究证实 ,利用耐药逆转剂、基因治疗及免疫治疗可不同程度逆转MDR。
出处 《国外医学(肿瘤学分册)》 2004年第8期635-637,共3页 Foreign Medical Sciences (Cancer Section)
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参考文献14

  • 1Lopes EC, Garcia M, Benavides F, et al. Multidrug resistance modulators PSC 833 and CsA show differential capacity to induce apoptosis in lymphoid leukemia cell lines independently of their MDR phenotype. Leuk Res, 2003, 27(5):413-423.
  • 2Ganeshaguru K, Wickremasinghe RG, Jones DT, et al. Actions of the s elective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro. Haematologica, 2002,87 ( 2 ): 167-176.
  • 3Inoue H, Takemura H, Kawai Y, et al. Dexamethasone-resistant human Pre-B leukemia 697 cell line evolving elevation of intracellular glutathione level: an additional resistance mechanism. Jpn J Cancer Res, 2002, 93(5): 582-590.
  • 4Mistry P, Stewart AJ, Dangerfield W, et al. In vitro and in vivo characterization of XRl1576, a novel, orally active, dual inhibitor of topoisomerase Ⅰ and Ⅱ .Anticancer Drugs,2002,13(l):15-28.
  • 5Stuart DD, Kao GY, Allen TM. A novel, long-circulating, and functional liposomal formulation of antisense oligodeoxynucleotides targeted against mdrl. Cancer Gene Ther, 2000,7 (3): 466-475.
  • 6Wu H, Hait WN, Yang JM. Small interfering RNA-induced suppression of MDB1 (P-glycoprotein) restores sensitivity to multidrug- resistant cancer cells. Cancer Res,2003,63(7): 1515-1519.
  • 7Cotter FE. Antisense therapy of hematologic malignancies. Semin Hematol, 1999,36(4 Suppl 6) :9-14.
  • 8Johnson TA, Press OW. Therapy of B-cell lymphomas with monoclonal antibo- dies and radioimmunoconjugates: the Seattle experience. Ann Hematol,2000, 79(4): 175-182.
  • 9Alas S, Emmanouilides C, Bonavida B. Inhibition of interleukin 10 by Rituximab results in down-regulation of Bcl-2 and sensitization Of B-cell non-Hodgkins's lymphoma to apoptosis. Clin Cancer Res, 2001,7 ( 3 ):709-723.
  • 10Alas S, Ng CP, Bonavida B. Rituximab modifies the Cisplatin-mitochondrial signaling pathway, resulting in apoptosis in Cisplatin-resistant non- Hodgkin's lymphoma. Clin Cancer Res, 2002,8 (3): 836-845.

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