血管内皮生长因子和微血管密度在食管癌中的临床意义

Clinical Value of the Expression of VEGF and MVD in the Esophageal Carcinoma

目的:探讨VEGF表达和MVD与食管癌临床病理指标和预后的相关关系。方法:用免疫组化法检测43例食管癌VEGF蛋白表达和MVD,应用等级相关检验研究VEGF和MVD与食管癌临床病理指标、局控率、总体生存率及无瘤生存率的相关关系。结果:VEGF表达与食管癌T分期呈正相关;MVD与病灶部位、组织学分化相关。多因素分析显示切缘阳性是影响局控率的预后因素;病灶部位、切缘阳性、T分期和VEGF表达是影响总体生存率和无瘤生存率的预后因素;MVD与预后无显著相关。结论:VEGF可能反映食管癌病变进展情况,并有助于预后判断,值得今后扩大样本量进一步研究。

Objective: The correlation of the expression of VEGF and MVD and Clinical pathological endpoints and prognosis of esophageal carcinoma was determined. Methods: In 43 cases, expression of VEGF and MVD of esophageal carcinoma were examined using immunohistochemical staining, the correlation of VEGF and MVD and Clinical pathological endpoints, local control rate, disease-free survival rate and overall survival rate were analyzed by using Pearson's rank correlation method. Results: The expression of VEGF has a positive correlation with T classification. There was no relationship between MVD and tumor location and histological stage. Multivariate analysis demonstrated that positive margin is the independent prognostic factor for local control rate, and Tumor location, positive margin, T classification and expression of VEGF were that for disease-free survival rate and overall survival rate, MVD had no significant relationship with prognosis. Conclusions: VEGF may reflect the disease progression of esophageal carcinoma, and benefit for prognostic evaluation, which is worth further study by more samples.