宫颈糜烂与解脲支原体、沙眼衣原体感染关系的临床研究

Clinical Study on the Relationship Between Erosion of Cervix and Infection of Ureaplasma Urealyticum and Chlamydia Trachomatis

目的 研究解脲支原体、沙眼衣原体感染与宫颈糜烂的关系。方法 用聚合酶链反应 (PCR)法对 3 2 4例宫颈糜烂患者 (观察组 )、3 2 4例无宫颈糜烂的宫颈炎患者 (对照组 )进行解脲支原体、沙眼衣原体的检测。结果 观察组解脲支原体、沙眼衣原体总检出率为 2 0 .68% ,显著高于对照组的 9.2 6% (P <0 .0 1) ;其中轻度糜烂患者检出率为 6.5 9% ,中度 2 7.18% ,重度 5 1.85 %。轻、中、重度宫颈糜烂各检出率经统计学处理有显著性差异 (P均 <0 .0 1) ;单纯解脲支原体检出率为 12 .65 % ,单纯沙眼衣原体检出率为 5 .2 5 % ,两者混合感染检出率为 2 78% ,解脲支原体检出率显著高于沙眼衣原体 (P <0 .0 1) ;有不洁性生活史者阳性检出率为 44 .74% ,显著高于无不洁性生活史者的 13 .3 1% (P <0 .0 1)。结论 解脲支原体、沙眼衣原体感染是引起宫颈糜烂的重要因素。

Objective To probe into the relationship between erosion of cervix and infection of Ureaplasma Urealyticum (UU) and Chlamydia Trachomatis(CT).Methods Polymerase chain reaction (PCR) technique was used to detect UU and CT for 324 women with erosion of cervix(case group)and 324 women with cervicitis(control group).Results The total positive rate of UU,CT was 20.68% in 324 women with erosion of cervix and was significantly higher than control group (9.26%) (P<0.01). The positive rate of UU,CT in the low-degree,median-degree,high-degree erosion of cervix was 6.59%?27.18%?51.85% respectively.The positive rate of UU,CT in median degree erosion was significantly higher than that of low degree by statistics (P<0 01) and also that of high-degree was significantly higher than that of median degree (P<0.01).The positive rate of UU was 12.65%,CT was 5.25% and the co-infection of two was 2 78%,the positive rate of UU was significantly higher than CT(P<0.01). The positive rate of UU,CT in the group of women with non-clean sexual intercourse was 44.74% and was significantly higher than that of control group 13.31%(P<0.01).Conclusion The infection of UU and CT is a factor causing erosion of cervix.