摘要
目的 :探讨CD4 4s在肺癌组织中的表达及其临床意义。方法 :采用免疫组化方法检测 117例原发性肺癌的CD4 4s异常表达。结果 :CD4 4s在小细胞肺癌 (SCLC)不表达 ,而表达于非小细胞肺癌 (NSCLC)中 ,并且鳞癌的CD4 4s表达强度明显强于腺癌 (P <0 0 5 ) ;未发生淋巴结转移的肺癌病例中CD4 4s的表达明显高于已经发生转移的病例 (P <0 0 1) ;按照临床肿瘤TNM分期 ,早期肺癌的CD4 4s表达显著高于进展期肺癌 (P <0 0 5 )。结论 :CD4 4s对肺癌组织的病理类型、淋巴结转移。
AIM: To investigate expression of CD44s in lung cancer and it's clinical significance. METHODS: A total of 117 primary lung cancer from patients were examined for CD44s expression by immunohistochemical staining. RESULTS: CD44s mostly expressed in non-small cell lung cancer (NSCLC) but not in small ecll lung cancer (SCLC), and squamous cell carcinoma(SCC) showed much stronger expression of CD44s than adenocarcinoma(ADC)(P<0.05). In comparison of the lung cancer with/ without lymph node metastasis, the latter showed stronger expression of CD44s(P<0.01). According to TNM, there was a distinct statistic difference between early stage and advanced stage(P<0.05). CONCLUSION: CD44s might be a better indicant in histological classification of lung cancer, lymph node metastasis, clinical stage and prognosis.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2004年第8期1489-1491,共3页
Chinese Journal of Pathophysiology
基金
广东省卫生厅科技基金资助项目 (No A2 0 0 0 6 17)
深圳市卫生科技基金资助项目 (No .2 0 0 0 0 4 0 5 7)
