压电石英晶体传感器中的温度效应

Effect of temperature on the frequency shift of piezoelectric quartz crystal biosensor

目的 探讨温度因素对压电石英晶体传感器检测频率变化的影响。方法 在传感器体系中 ,于不同温度条件下测定空白芯片、已包被芯片在气相中和液相中频率达到稳定的时间 ,和抗原抗体反应时间随温度变化量。结果 随着外界温度升高 ,频率呈下降的趋势 ;外界温度降低 ,频率呈上升的趋势。环境温度过高或过低都会延长检测时间。结论 传感器对温度的变化较为敏感 ,故应在检测前进行检测池的预热 。

Objective To discuss the effect of temperature on the frequency shift of piezoelectric quartz crystal biosensor.Methods To detect the time consumed before frequency becoming stable in air and in solution under different temperature.And the time varied with the change of temperature.Results The frequency decreased with the increase of environmental temperature,while increased when the temperature declined.Much higher or lower temperature will both prolong the detection time.Conclusion Biosensor is sensitive to the alteration of temperature,so the detection well must be pre heated before operation.And the surrounding temperature should be kept in optimal range.