1Bissonnette M,Khare S,von lintig FC,et al.Mutation and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: effects on mitogen-activated protein kinase,cyclooxygenase-2,and cyclinD1[J].Cancer Res,2000,60(16):4602
2Jaiswal AS,Marlow BP,Gupta N,et al.Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells[J].Oncogene,2002,21:8414
3Mei JM,Hord NG,Winterstein DF,et al.Differential expression of prostaglandin endoperoxide H synthase-2 and formation of activatedβ-catenin-LEF-1 transcription complex in mouse colonic epithelial cells contrasting in Apc[J].Carcinogenesis,1999,20:737
4Potter JV.Colorectal cancer:molecules and populations[J].J Natl Cancer Inst,1999,91:916
5Fodde R,its R,Clevers H.APC,signal transduction and genetic instability in colorectal cancer[J].Nat Rev Cancer,2001,1:55
6Hovanes K,Li TW,Munguia JE,et al.Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer[J].Nat Genet,2001,28:53
7Maruyama K,Ochiai A,Akimoto S,et al.Cytoplaic beta-catenin accumulation as a predictor of hematogenous metastasis in human colorectal cancer[J].Oncology,2000,59:302
8Brabletz T,Hermann K,Jung A,et al.Expression of nuclear beta-catenin and c-myc is correlated with tumor size but not with proliferative activity of colorectal adenomas[J].Am J Pathol,2000,156:865
9O'Sullivan MJ,McCarthy TV,Doyle CT.Familial adenomatous polyposis from bedside to benchside[J].Am J Clin Pathol,1998,109:521
10Kemler R,Ozana M.Uvomorulin-catenin complex:cytoplaic anchorage of a Ca2+-dependent cell adhesion molecule[J].Bioessays,1989,11:88
二级参考文献21
1Levanon D, Goldstein RE, Bernstein Y,et al. Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors [J]. Proc Natl Acad Sci USA,1998,95(20) : 11590.
2Ishitani T, Ninomiya TJ, Nagai S, et al. The TAK1-NLKMAPK-related pathway antagonizes signaling between β-eatenin and transcription factor TCF[J]. Nature, 1999,399:798.
3Easwaran V, Pishvaian M, Byers S, et al. Cross-regulation of β-catenin-LEF/TCF and retinoid signaling pathways[J]. Curr Bio1,1999,9:1415.
4Pálmer HG, González-Sancho JM, Espada J,et al. Vitamin Ds promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling[J]. J Cell Biol, 2001,154 ( 2 ) : 369.
5Ilyas M, Tomlinson IPM. The interactions of APC, E-cadherin and β-catenin in tumour development and progression[J]. J Pathol, 1997,182 : 128.
6Dale TC. Signal transduction by the Wnt family of ligands[J]. Biochem J, 1998,329 : 209.
7Peifer M, Polakis P. Wnt signaling in oncogenesis and embryogenesis-a look outside the nucleus [J]. Science,2000,287(5458) :1606.
8Sakanaka C, Williams LT. Functional domains of axin[J]. J Biol Chem, 1999,274(20): 14090.
9Holcombe RF, Marsh JL, Waterman ML,et al. Expression of Wnt ligands and frizzled receptors in colonic mucosa and in colon carcinoma[J]. Mol Pathol, 2002,55:220.
10Korinek V,Barker N, Morin PJ,et al. Constitutive transcriptional activation by a β-catenin-tcf complex in APC colon carcinoma[J]. Science, 1997,275(5307): 1784.
3Huerta S. Recent advances in the molecular diagnosis and prognosis of colorectal eancer[J].Expert Rev Mol Diagn, 2008,8(3) :277.
4Kim E,Jeon IS,Kim JW,et al. An MTT-based method for quantification of periodontal ligament cell viability[J]. Oral Dis,2007,13(5) :495.
5Cieslak D,Lazou A. Regulation of BAD protein by PKA, PKCdelta and phosphatases in adult rat cardiac myocytes subjected to oxidative stress[J]. Mol Cells, 2007,24 (2) : 224.
6Ohkubo N, Vitek MP, Morishima A, et al. Reelin signals survival through Src family kinases that inactivate BAD activity[J].J Neurochem,2007,103(2) :820.
7J eong EG, Lee SH, Kim SS, et al. Immunohistochemical analysis of phospho-BAD protein and mutational analysis of BAD gene in gastric carcinomas[J].APMIS, 2007,115 (8) :976.
8Yoo NJ,Soung YH, Lee SH, et al. Mutational analysis of the BH3 domains of proapoptotic Bcl 2 family genes Bad, Bmf and BcI-G in laryngeal squamous cell carcinomas[J].Tumori, 2007,93 (2) : 195.
9Maiuri MC, Criollo A, Tasdemir E, et al. BH3-only pro teins and BH3 mimetics induce autophagy by competitive-ly disrupting the interaction between Beclin 1 and Bcl-2/ Bcl-X(L) [J].Autophagy,2007,3(4) :374.
10Liu XS,Jiang J. Molecular mechanism of matrine-induced apoptosis in leukemia K562 cells[J]. Am J Chin Med, 2006,34(6) : 1095.
