新疆维吾尔族2型糖尿病家系中糖尿病高危人群高危因素的研究

High-risk factors in the diabetic high risk group of type 2 diabetic family of Sinkiang Uygur nationality

目的探讨新疆糖尿病高发民族维吾尔族中的糖尿病高危人群以及是否有糖尿病高危因素。方法收集新疆和田地区维吾尔族2型糖尿病家系21个,共372例,男159例,女213例。按与先证者血象关系远近分为3组,分别为同胞组(61例)、子代及亲代组(26例)、三级亲属组(82例),另设糖尿病家族中非血缘关系的非糖尿病患者,设为对照组(78例),观察各组的血糖、血脂、胰岛素等指标。结果同胞组体质量指数明显高于其他3组,同胞组收缩压高于三级亲属组,但与子代及亲代组差异无显著性意义(P>0.05)。同胞组与子代及亲代组之间胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇差异均无显著性意义(P>0.05)。同胞组的胆固醇、低密度脂蛋白胆固醇高于三级亲属组(q=4.75,P<0.05)。同胞组与正常对照组胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇差异无显著性意义(P>0.05),同胞组三酰甘油[(1.74±0.69)mmol/L]高于正常对照组[(1.47±0.89)mmol/L](q=5.43,P<0.01)。各组间空腹血糖及负荷后血糖差异无显著性意义(P>0.05);同胞组空腹胰岛素[(14.67±11.88)mmol/L]显著高于正常对照组[(9.62±6.79)mmol/L](q=7.97,P<0.01);同胞组和子代及亲代组的负荷后胰岛素水平相同,但显著高于三级亲属组(q=5.35,P<0.01)。结论维吾尔族2型糖?

AIM:To explore the diabetic high risk group in the Uygur nationality,which has the high incidence of diabetes mellitus(DM) in Sinkiang Uygur autonomous region,and to study whether there are high risk factors of DM.METHODS:Totally 372 cases(159 males and 213 females) of 21 type 2 diabetic families of Uygur nationality were collected from the Hetian area of Sinkiang Uygur autonomous region.All the patients were divided into 3 groups according to the relation of their hemogram with that of the propositus:sibling group(group A,n=61),filial and parental generation group(group B,n=26) and secondary parental group (group C,n=82).Another 78 non diabetic patients without blood relationship were selected from the diabetic families as the controls(control group).The indexes of blood glucose,blood lipid and insulin were observed in all the groups.RESULTS:The body mass index(BMI) in group A is obviously higher than those in the other 3 groups.The systolic pressure in group A was higher than that in group C,but insignificantly different from that in group B(P >0.05).There were no significant differences in cholesterol(C),triacylglycerol(TG),high density lipoprotein C(HDL C) and low density lipoprotein C(LDL C) between group A and group B(P >0.05).The levels of C and LDL C in group A were higher than those in group C(q=4.75,P< 0.05).There were no significant differences in C,HDL C and LDL C between group A and the spouse control group(P >0.05).The TG level in group A[(1.74±0.69) mmol/L] was higher than that in the spouse control group[(1.47±0.89)mmol/L] (q=5.43,P< 0.01).The fasting blood glucose and that after load were not significantly different among the groups (P >0.05).The fasting insulin in group A[(14.67±11.88) mmol/L] was significantly higher than that in the spouse control group[(9.62±6.79)mmol/L](q=7.97,P< 0.01).The insulin levels after load in groups A and B were the same,but significantly higher than that in group C (q=5.35,P< 0.01).CONCLUSION:In the Uygur type 2 diabetic families,the brothers or sisters of the patients are the high risk group of DM relatively,and their TG,waist to hip ratio,BMI,fasting insulin and insulin after load are the high risk factors relatively.