抑郁症伴失眠患者的多道睡眠图研究

Study on the polysomnography of depressive patients with insomnia

目的探讨抑郁症伴失眠患者多道睡眠图中睡眠参数改变的生物学特点和可能机制。方法对35例抑郁症伴有失眠患者和40例正常人进行多道睡眠图检查,并进行睡眠参数比较。结果与对照组(12.45±3.17)min比较,抑郁症组睡眠潜伏期(26.84±5.31)min长,差异有非常显著性意义(t=14.4528,P<0.0001),且抑郁症组的觉醒次数多(P<0.001)、实际睡眠时间少(P<0.05),睡眠效率低(P<0.0001),浅睡(Ⅰ,Ⅱ期睡眠)增多(P<0.001),而深睡(Ⅲ,Ⅳ期睡眠)减少(P<0.0001),快速眼动睡眠时间延长、比例增加(P<0.0001),其潜伏期明显减少(P<0.0001)。结论抑郁症伴失眠患者存在诸多多道睡眠图异常,并与症状相一致,提示该失眠的发生机制可能同抑郁症的发病机制一致。

AIM:To explore the biological features of the changes in sleeping parameters of polysomnography(PSG) in depressive patients with insomnia,and to study its possible mechanism.METHODS:PSG was preformed in 35 depressive patients with insomnia and 40 normal controls,and the sleep parameters were compared and analyzed.RESULTS:The sleep latency in the depression group[(26.84±5.31) minutes] was longer than that in the control group[(12.45±3.17) minutes](t=14.452 8,P< 0.000 1).There were more waking frequency(P< 0.00 1),less total sleep duration(P< 0.05),lower sleep efficiency(P< 0.000 1),increased light sleep(stage Ⅰand Ⅱ)(P< 0.001),but decreased deep sleep(stage Ⅲand Ⅳ)(P< 0.000 1),prolonged rapid eye movement sleep(REMS) latency and increased REMS rate(P< 0.000 1) were found in the depression group.CONCLUSION:There are many PSG abnormalities,which are consistent with the symptoms of depressive patients with insomnia,indicating that the pathogenesis of sleep disturbance may result from the etiology of depression.