慢性阻塞性肺疾病患者抑郁情绪对肺功能和生活质量的影响

Effect of depression on lung function and quality of life in patients with chronic obstructive pulmonary diseases

目的探讨慢性阻塞性肺疾病(chronicobstructivepulmonarydisease,COPD)患者抑郁情绪对肺功能的影响,总结其规律性。方法87例COPD患者入院后1周内分别接受了肺功能、血气检查,评估不同抑郁情绪COPD患者的肺功能、生活质量,并比较其血气指标。结果87例COPD患者共检出抑郁情绪者42例(48%),平均汉密顿抑郁量表(HAMD)评分为10.8±2.2,按不同抑郁程度分组后,无或轻度抑郁患者的各项肺功能指标和血气检测值[PaCO2(6.25±0.86)kPa和PaO2(9.81±0.83)kPa]明显优于中、重度抑郁患者[(7.14±0.91),(7.94±0.95)kPa](t=2.239-3.172;P均<0.01～0.05),同时前者生活质量总均分和各分项指标均明显低于后者(t=2.359-3.327;P均<0.01-0.05)。结论COPD患者常伴有明显的抑郁情绪,对其进行干预有可能改善肺功能、血气指标和生活质量。

AIM:To explore the influence of depression on lung function and quality of life(QOL) in patients with chronic obstructive pulmonary diseases(COPD),and to summarize its regularity.METHODS:Lung function and blood gas were examined in 87 patients with COPD one week after hospitalization,and the lung function and QOL were evaluated in the COPD patients with depression of different degrees,then their blood gas indexes were compared.RESULTS:Among the 87 patients with COPD,42(48%) were diagnosed as having depression,the mean score of Hamiltion rating scale for depression(HAMD) was 10.8±2.2.After grouping according to the depression degree,the values of lung function indexes and blood gas indexes[PaCO2:(6.25±0.86) kPa and PaO2:(9.81±0.83) kPa] in the patients without or with mild depression were obviously superior to those in the patients with moderate and severe depression[(7.14±0.91),(7.94±0.95) kPa](t=2.239-3.172;all P< 0.01-0.05),and the scores on QOL of the former were obviously lower than those of the latter (t=2.359-3.327;all P< 0.01-0.05).CONCLUSION:COPD patients are always complicated with obvious depression,and psychological intervention may improve their lung function,blood gas indexes and QOL.