男性精神分裂症患者攻击行为与血浆5-羟色胺、血清睾酮水平的相关性

Relationship between impulsive aggression and levels of plasma serotonin and serum testosterone in male schizophrenia

目的探讨人口学特征和血浆5-羟色胺、血清睾酮与男性精神分裂症患者攻击行为的关系。方法将70例首次发病的男性精神分裂症患者,以既往史和外显攻击行为量表评分区分,有攻击行为者为研究组(n=36),无攻击行为者为对照组(n=34),比较两组血浆5-羟色胺、血清睾酮的水平。结果研究组5-羟色胺水平[(50.23±6.73)mg/L]较对照组[(58.18±7.42)mg/L]明显降低,差异有显著性意义(t=4.70,P<0.01);睾酮的水平[(5.01±0.99)mg/L]较对照组[(4.02±0.87)mg/L]显著升高,差异有显著性意义(t=4.43,P<0.01);5-羟色胺、睾酮水平与攻击性行为显著相关(r=-0.38,0.40;P均<0.05)。结论5-羟色胺、睾酮水平可能与男性精神分裂症患者攻击行为有关。

AIM:To explore the demography characteristics and the relationship between impulsive aggression and plasma serotonin and serum testosterone in male schizophrenia.METHODS:A total of 70 male patients with first dementia praecox were selected.According to the past violence history and modified overt aggression scale (MOAS),70 schizophrenic patients were divided into research group (n=36) and control group(n=34).Plasma serotonin and serum testosterone levels were compared between the two groups.RESULTS:Plasma serotonin level[(50.23±6.73) mg/L] was significantly decreased in the research group as compared with the control group [(58.18±7.42) mg/L],which indicated significant difference (t=4.70, P< 0.01); and serum testosterone level[(5.01±0.99) mg/L] was significantly increased as compared with the control group [(4.02±0.87) mg/L],which indicated significant difference(t=4.43,P< 0.01);The levels of serotonin and testosterone were significantly correlated to aggressive behaviour(r=-0.38,0.40;allP< 0.05). CONCLUSION:Aggressive behaviour may be related to plasma serotonin and serum testosterone levels in schizophrenia.