糖尿病周围神经病变与各影响因素的相关性分析(英文)

Relationships between diabetic peripheral neuropathy and affective factors

背景糖尿病周围神经病变的发生是多因素综合影响的结果,其中高血糖是最重要的影响因素已形成共识。目的分析糖尿病周围神经病变与各影响因素之间的关系,进一步阐明严格控制血糖的重要性。设计以诊断为依据的横断面研究。地点和对象收集1999-06/2001-06在本院内分泌科住院治疗患者120例,均符合1999年制订的糖尿病诊断标准。方法测定120例糖尿病患者周围神经传导速度,与各影响因素进行逐步回归分析,并以糖化血红蛋白(HbA1c)不同切点进行分组,将各周围神经传导速度进行t检验。主要观察指标糖尿病患者各周围神经传导速度、病程、空腹血糖、餐后2h血糖、年龄、总胆固醇、三酰甘油、HbA1c、果糖胺、C肽、餐后2hC肽、以及24h尿蛋白总量。结果各影响因素中,HbA1c有4项显著相关,其次为年龄(3项),再次为空腹血糖和病程(2项),当HbA1c达到6.8时,开始出现周围神经传导速度的显著差异,HbA1c超过8.0时,所有的神经传导速度均出现明显差异。若去除病程和年龄因素后,HbA1c达到9.0时,所有神经传导速度方才出现显著差异。结论糖尿病周围神经病变与多种影响因素有关,相关性最强的是HbA1c,其次,病程和年龄也起到了非常重要的作用。

BACKGROUND:The developm ent of diabetic peripheral neuropathy is af-fected by m any factors and it is w ell know n that hyperglycem ia is the m ostsignificant one of the factors.O B JE C T IV E : To illustrate the im portance of glycem ic control and the re-lationship betw een diabetic peripheral neuropathy and each relative factor.D E SIG N :A retrospective controlled study based on diagnosis.SE T T IN G and P A R T IC IPA N T S: Totally 120 diabetic in-patients(according to standards in 1999)of the departm ent of endocrinology in ourhospital were collected from June 1999to June 2001.M E T H O D S:N erve conductive velocity(N C V )in 120diabetic patients w asdeterm ined.Step gradual regression analyses w ere perform ed betw een N C Vand all factors.N C V was divided into groups at different H bA lc levels,and ttest w as used.M A IN O U T C O M E M E A SU R E :E very nerve conductive velocity,course ofdisease,fasting blood sugar,post-prandialblood sugar,age,totalcholesterol,triglyceride,H bA 1c,FA ,C -peptide,post-prandial peptide and 24hours uri-nary protein w ere exam ined.R E SU L T S: A m ong the relative factors, the m ost significant difference w asobserved in H bA lc(4item s),then in age(3item s),FB S and the course ofdis-ease(2item s)respectively.The first significant change of N C V w as observedw hen H bA lC reached 6.8.Significantchanges w ere observed in allN C V w henH bA lc was greater than 8.0.The sam e changes happened w hen H bA lc w asgreater than 9.0,w hen the factors ofthe age and the course w ere elim inated.C O N C L U T IO N :A m ong the factors related to diabetic peripheral neuropa-thy, H bA lc expresses the closest correlation.The course and the age alsoplayed the extrem ely vital role.