对降低百合、首乌藤提取物中苯含量的工艺研究

Study on the Technology to Reduce Benzene Best of Caulis Polygoni Multifori and Bulbuslilii to Draw Benzene

目的 研究降低百合和首乌藤提取物中苯含量的最佳提取工艺,使苯含量不超过国家标准2 μg/g,从而保证百乐眠胶囊使用时的安全性。方法 分析影响提取物所得干膏中苯含量的各种因素,采用正交试验进行比较分析。结果 通过实验得出最佳提取工艺:乙醇浓度40%,第1次5倍量提取时间为3 h,第2次3倍量提取时间为2 h。结论 此法可以明显降低提取物中的苯含量。

Objective To study the technology to reduce the content best of Caulis Polygoni Multifori and Bulbuslilii to draw benzene. Make the content of benzene not exceed 2 μg/g, thus guarantee the security of Bilemian Capsule. Methods Analyse the influence factors of drawing benzene and summarize each heavy factor relatively by orthogonal test. Results The best technology:the density of ethanol is 40%, draw time as 3 hours the first time and quantity of 5 times, draw time as 2 hours the second time and quantity of 3 times. Conclusion This technology can reduce the content of benzene to draw.