利培酮治疗抽动-秽语综合征21例

Effect Comparison between Risperdal and Haloperidaol for Tour ette Syndrome

目的 :观察利培酮治疗少年儿童抽动 秽语综合征 (Tourette)综合征的疗效及不良反应。方法 :随机抽取符合CCMD Ⅲ诊断标准的Tourette综合征患儿 3 9例 ,随机分为治疗组 2 1例和对照组 18例。在精神治疗基础上 ,治疗组给予利培酮 0 .2 5～ 2 .0 0mg·d 1 ,对照组给予氟哌啶醇 1.0mg·d 1 ,均分两次口服。 4周后进行疗效评定。结果 :治疗组有效率 85 .7% ,对照组有效率 83 .3 % ( χ2 =0 .0 42 ,P >0 .0 5 )。治疗组脱落 1例 ,有轻微坐立不安 4例 ;对照组脱落 2例 ,嗜睡6例 ,静坐不能与反应迟钝 5例。两组不良反应比较差异有极显著性 ( χ2 =7.70 ,P <0 .0 1)。结论 :利培酮治疗Tourette综合征与氟哌啶醇疗效相近 ,但不良反应较氟哌啶醇明显减少。

Objective:To study the effectiveness and the s ide effects of risperdal in the treatment of children and adolescents with Toure tte syndrome. Methods:A total of thirty-nine outpatients with the age of 7-14 years were diagnosed by CCMD-III standard as Tourette syndrome patien ts, and randomized into two groups. Twenty-one patients in group one were treat ed wtih risperdal, and eighteen patients in group two with haloperidol as the co ntrol for a period of 4 weeks. All the patients were also provided psychological therapy. Results:The effective rates had no significant differenc e between risperdal group (85.7%) and haloperidol group (83.3%) (χ 2=0.042, P>0.05). Only two patients in risperdal group lost contact, and four patien tts were slightly restless. In control group, two cases lost contact, six cases were sleepy, and five cases were restless and slow. The side effects had signifi cant difference between the two groups (χ 2=7.70, P<0.01). Conclusion:Both risperdal and haloperidol are effective in treatment of tourette syndrome but risperdal has less side effects.