5[1]Katsuki A, Sumida V, Murashima S, et al. Serum levels of tumor necrosis factor - alpha are increased in obese patients with noninsulin- dependent diabetes mellitus[J] .J Clin Endorinol Metab, 1998, 83: 859 - 862.
6[2]Raven GM. Role of insulin resistance in human disease [ J]. Djabetes, 1988, 37:1595 - 1607.
7[3]Hotamisligil GS, Peraldi P, Budavari- A, et al. IRS - 1 - mediated inhibition of insulin receptor tyrosine kinase activity in TNF - alpha- and obesity - induced insulin resistance [J]. Science, 1996, 271:665 - 668.
8[4]Paz K, Hemi R, Leroith D, et al. A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS - 1 and IRS - 2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin - induced tyrosine phosphorylation [J] .J Biol Chem, 1997, 272: 29911 -29916.
9[5]Stephens JM, Lee J, Pilch PF. TNF - a induced insulin resistance in 3T3 - L1 adipocytes is accompanied by a loss of insulin receptor substrate - 1 and GLUT4 expression without a loss of insulin receptor- mediated signal transduction[J]. J Biol Chem, 1997, 272:971- 976.
10[6]Roden M, Price TB, Perseghin G, et al. Mechanism of free fatty acid- induced insulin resistance in humans[J] .J Clin Invest, 1996,97: 2859 - 2865.