3～6岁缺铁性贫血患儿免疫功能变化研究

Immune Function Change of the Children Aged from 3 to 6 Years Old with Iron-deficiency Anemia

目的 研究 35例 3～ 6岁缺铁性贫血 (IDA)患儿血清中免疫球蛋白 (Ig)和外周血T淋巴细胞亚群变化。方法 采用透射比浊法和抗体致敏红细胞花球试验检测了 35例 3～ 6岁IDA患儿和同龄的 35例健康儿童血清中Ig和外周血T淋巴细胞亚群 ,并进行比较。结果 35例IDA患儿血清IgG、IgA、IgM与对照组比较无显著性差异 (P >0 .0 5 ) ,外周血中CD3 、CD4及CD4/CD8比值明显低于对照组 (P <0 .0 1) ,CD8与对照组比较无显著性差异 (P >0 .0 5 ) ,CD3 、CD4与贫血程度呈正相关 (r值分别为 0 85、0 91,P值 <0 .0 1) ,CD8与贫血程度无相关 (r =0 .17,P >0 .0 5 )。结论 IDA主要影响 3～ 6岁患儿的细胞免疫功能 ,不影响其体液免疫功能。

Objective To study the change of Ig in serum and of the sub-group of peripheral blood T-lymphocyte in the children aged from 3 to 6 years old with IDA.Methods Transmission turbidimetry and anti-body sensitized red cell Rose test were applied to detect Ig in serum and the sub-group of peripheral blood T-lymphocyte in 35 children aged from 3 to 6 years old with IDA and 35 healthy children;the results were compared.Results The IgG,IgA and IgM in serum of the 35 children with IDA showed no significant difference with those in the control group (P>0.05);the CD 3,CD 4 and the ratio of CD 4/CD 8 in the peripheral blood were much higher than those in the control group (P<0.01);CD 8 had no dominant difference with that in the control group (P>0.05);CD 3 and CD 4 were positively related with the severity of anaemia (r=0.85 and 0.91,P<0.01) while CD 8 had no relation with the severity of anaemia (r=0.17,P>0.05).Conclusions IDA mainly interferes with the cellular immune function of children aged from 3 to 6 years old with IDA,but doesn't interfere with other body fluid immune function.