生活习性与帕金森病关系的研究

Study on the correlation between Parkinson's disease and living habits

目的 探讨生活习性与帕金森病 (PD)的关系。方法 选取在北京地区 5 5岁以上PD患病率调查中确诊及在北京协和医院帕金森病研究中心诊治的患者共 114例 ;以及性别、民族及居住地与其匹配的对照者 2 0 5名的一般资料及吸烟、饮茶、饮酒等生活习性进行调查 ,并加以相关分析。结果 吸烟者和饮茶者患PD的危险性低于对照组 ,OR值分别为 0 5 38(95 %CI:0 2 90 ,0 998)和 0 199(95 %CI:0 114 ,0 346 )。饮酒者与PD关联无统计学意义。结论 生活习性中吸烟和饮茶同PD存在负相关 ,即有保护作用 。

Objective To explore the correlation between Parkinson's disease(PD) and living habits.Methods 114 PD cases from ongoing PD prevalence survey in Beijing region and the neurological clinic center of Beijing Union Hospital and 205 controls matched on gender, race and residence were recruited in this study. Through in-person questionnaire interview, general data and living habits such as smoking, tea drinking and alcohol drinking were obtained and analyzed by population-based case control study.Results We observed reduced risk for PD in smokers(OR:0.538; 95%CI: 0.290, 0.998) and tea-drinkers(OR:0.199; 95%CI:0.114,0.346). There was no significant correlation between alcohol drinking and PD.Conclusion An inverse correlation exists in PD with smoking or tea drinking except for alcohol drinking.