摘要
①目的 探讨肿瘤抑制基因PTEN、P16与原发性宫颈癌的关系。②方法 应用免疫组化技术 ,检测2 0例正常宫颈组织和 71例原发性宫颈癌组织PTEN、P16蛋白表达水平。③结果 PTEN蛋白在宫颈癌组织中阴性表达率为 33.80 % ,PTEN的阴性表达与鳞癌关系密切 (χ2 =7.5 3,P <0 .0 5 ) ,与腺癌无明显关系。P16蛋白阴性表达率为 11.2 6 % ,P16蛋白的阴性表达与宫颈癌无明显关系 ;在宫颈鳞癌组织中P16蛋白过表达率为 5 6 .4 5 % ,两者关系密切 (χ2 =5 .99,P <0 .0 5 )。④结论 PTEN蛋白阴性表达在宫颈鳞癌中起重要作用 ,与腺癌关系不密切。在宫颈鳞癌中P16蛋白的过表达较阴性表达更重要 ,可能是宫颈癌中高危人乳头状病毒感染的一种表现。
Objective To study the relationship between the tumor- suppressor protein PTEN and P16 and primary cervical cancers. Methods The expressions of PTEN and P16 were detected in 20 normal cervical specimens and 71 primary cervical cancers by immunohistochemistry. Results The rate of negative PTEN expression was 33.80% in the cervical cancers,which was closely associated with squamous carcinomas (χ2=7.53,P<0.05), but not with cervical adenocarcinomas. The P16 protein was not detected in 11.26%. The negative expression of P16 was not associated with cervical carcinomas ,but over-expression of P16 was found in the specimens of squamous cell carcinomas, the incidence being 56.45%(χ2=5.99,P<0.05). Conclusion The negative expressionof PTEN plays an important role in squamous cell carcinomas of the cervix, but is not closely related with cervical adenocarcinomas. The over-expression of protein P16, which might be a sign of high-risk HPV infection in primary cervical carcinomas, is more important than the negative expression.
出处
《齐鲁医学杂志》
2004年第3期227-229,共3页
Medical Journal of Qilu
