期刊文献+

pegvisomant研究现状及其在肢端肥大症中的应用 被引量:1

下载PDF
导出
摘要 Pegvisomant是一种生长激素(growth hormone,GH)受体拮抗剂.随着研究的深入,人们对长效pegvisomant在对肢端肥大症患者的治疗作用和在体内的代谢有了更多了解.下面就pegvisomant的研究现状作一综述.
作者 王雄伟 雷霆
出处 《中国临床神经外科杂志》 2004年第4期312-314,317,共4页 Chinese Journal of Clinical Neurosurgery
  • 相关文献

参考文献14

  • 1Starr R,Hilton DJ.Negative regulation of the JAK/STAT pathway [J].Bioessays,2000,21:47~52.
  • 2Clark R,Olson K,Fuh G,et al.Long-acting growth hormones produced by conjugation with polyethylene glycol [J].Biol Chem,1996,271:21969~21977.
  • 3Cunningham BC,Wells JA.Rational design of receptorspecific variants of human growth hormone [J].Proc Natl Acad Sci USA.1991,88:3407~3411.
  • 4Ross R J,Leung KC,Maamra M,et al.Binding and functional studies with the growth hormone receptor antagonist,B2036-PEG(pegvisomant),reveal effects of pegylation and evidence that it binds to a receptor dimmer [J].Clin Endocrinol Metab,2001,86:1716~1723.
  • 5Pollak M,Blouin MJ,Zhang JC,et al.Reduced mammary gland carcinogenesis in transgenic mice expressing a growth hormone antagonist [J].Br J Cancer,2001,85:4013~4021.
  • 6Wilson ME.Insulin-like growth factor Ⅰ (IGF-Ⅰ ) replacement during growth hormone receptor antagonism normalizes serum IGF-binding protein-3 and markers of bone formation in ovariectomized rhesus monkeys [J].J Clin Endocrinol Metab,2000,85:1557~1562.
  • 7Burt M,Ho K.Comparison of efficacy and tolerability of somatostatin analogs and other therapies for acromegaly [J].J Endocrine,2003,20(3):299~306.
  • 8Trainer PJ,Drake WM,Katznelson L,et al.Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant [J].N Engl J Med,2000,342:1171~1177.
  • 9van der Lely A J,Hutson R K,Trainer P J,et al.Longterm treatment of acromegaly with pegvisomant,a growth hormone antagonist [J].Lancet,2001,358:1754~1759.
  • 10Peacey SR,Toogood AA,Veldhuis JD,et al.The relationship between 24-hour growth hormone secretion and insulin-like growth factor I in patients with successfully treated acromegaly:impact of surgery or radiotherapy [J].J Clin Endocrinol Metab,2001,86:259~266.

同被引文献9

引证文献1

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部