小剂量芬太尼加异丙酚对初孕妇人流术的镇痛观察

Clinical Study of Analgesic Effects of Small Dosage Fentanyl andPropofol Intravenous Anesthesia in Artificial Abortion of First Pregnancy

目的 对初孕妇人流术单纯静注异丙酚和静注芬太尼 ,异丙酚两组病人镇痛效果 ,安全性及副作用进行评价。方法 将 2 0 0例无全身性疾患 .无麻醉药过敏史及镇痛 ,镇静药成瘾史的初孕妇分为单纯静注异丙酚 (异丙酚组 ) 10 0例和先静注 0 .0 5mg芬太尼 1-2分钟后再静注异丙酚诱导。维持麻醉 (芬异组 ) 10 0例。结果 两组病人一般情况及离院时间无显著性差异 (P >0 .0 5 ) ) ,芬异组异丙酚诱导用量较异丙酚组明显减少 (P <0 .0 1) ,芬异组扩宫阶段及吸引阶段镇痛效果明显优于异丙酚组 (P <0 .0 1) ,芬异组较异丙酚组清醒时间略延长 (P <0 .0 5 ) ,而离院时间两组无显著差异 (P >0 .0 5 )。结论 :初孕妇行异丙酚无痛人流时 ,先静注小量芬太尼可明显增强镇痛作用 ,有效消除扩宫痛 ,而不增加副反应。

Objective Propofol single anesthesia and propofol, fentanyl combined anesthesia anesthetic analgesies used in first pregnancy artificial abortion were studied.Methods 200 patients of first pregnancy with no drug abused history,systematic disease and anaesthetic allergic history were randomly and equally devided into 2 groups. Group A:single propofol i.v. Group B:fentanyl compatible with propofol i.v. Two group's Antalgic effect, security and side effect were assessed.Results 1.There were no difference between 2 groups in average depart time (p>0.05) 2.The dosage of propofol in group B were decreased significantly compared with that in group A (p< 0.01)3.The recovery process in group B were slightly delayed compared with that in group A (p<0.05).Conclusions Fentanyl may enhance the antalgic effect of propofol and effectively ease the enlarge-cervical ache without additional side effect.