三相避孕片的孕激素活性研究

Experimental study on progestogen activity of triphasic contraceptive tablets

目的 了解三相避孕片的孕激素作用及活性。方法 用雌性幼龄小鼠子宫增重及雌性幼龄家兔子宫内膜转化试验方法观察国产 (卡丽瑞 )和进口 (特定偶 )三相避孕片的孕激素活性 ;用成年雌家兔去卵巢一周后子宫组织细胞液 ,通过放射受体分析测定两药对孕激素受体作用。结果 与阴性对照组比 ,卡丽瑞和特定偶各相均使雌性幼龄小鼠子宫重量增加 (P <0 0 1) ,并使兔子宫内膜增厚。卡丽瑞对子宫增重和促进家兔子宫内膜增厚作用还显示剂量依赖关系。放射受体分析结果表明 ,卡丽瑞和特定偶对孕激素受体均具较强亲和力 ,与孕激素标准品活性十分相似 ;三者之间差异无显著性。结论 说明国产和进口三相避孕片具有明显孕激素作用及活性。

Aim To study the progestogen effect and activity of triphasic contraceptive tablets.Methods The progestogen activity of triphasic contraceptive tablets (kalirui and trinordiol) was evaluated through uterus weight increase test of female young mice and endometrium translation examination of female young rabbits. Radialized receptor analysis was used to determine the effect of the triphasic contraceptive tablets on progestogen receptor by the uterus histiocyte from the adult female rabbits whose ovaries had been taken away a week ago. Results Compared with the negative control, triphasic contraceptive tablets kalirui andtrinordiol in three phase groups not only enhanced uterus weight of female young mice, middle and high dose groups obviously accelerated the uterus weight increase ( P <0 01), but incrassated the endometrium of the rabbits, while Kalirui had a dose dependent effect on uterus weight increase and endometrium incrassation. The radialized receptor analysis indicated that kalirui and trinordiol had strong appetency to progestogen receptor, like the progestogen standard. There were no distinct differences among them. Conclusion Triphasic contraceptive tablets kalirui and trinordiol have apparent progestogen effect and activity.