肝长春口服液保肝抗纤维化作用的实验研究

Effect of Ganchangchun Oral Liquid on liver-protection and anti-fibrosis

目的 :观察中药肝长春 (鳖甲、人参、水蛭、黄芪等 )的保肝抗肝纤维化作用。方法 :用四氯化碳诱导大鼠肝纤维化模型 ,观察肝长春对大鼠肝功能、透明质酸 (HA)、Ⅳ型胶原 (Ⅳ C)、层粘蛋白 (LN)及肝组织病理学影响。结果 :肝长春能显著降低肝纤维化大鼠血清转氨酶、HA、LN及Ⅳ C(P <0 .0 5 ) ,并减轻肝脏的纤维增生程度 (P <0 .0 1)。结论

AIM: To observe the effect of the liver-protection and anti-fibrosis of Ganchangchun Oral Liquid(Carapax T.rionycis, Radix Ganseng Hirudo, Radix Astragali, etc.) METHODS: Hepatic fibrotic rat model was induced with carbon tetrachloride. The effect of Ganchangchun Oral Liquid on hepatic function, hyaluronic acid (HA), type Ⅳ collagen (Ⅳ-C), laminin (LN) and hepatic histopathology of the rats were detected. RESULTS: Ganchangchun Oral Liquid could decrease the level of transaminase, HA, LN and Ⅳ-C in the serum of rats with hepatic fibrosis significantly. Meanwhile, it could relieve the fibrotic degree of liver. CONCLUSION: To experimental rat with hepatic fibrosis, Ganchangchun Oral Liquid has prevention and treatment effect.