新生鼠脑缺血再灌注后海马CA1区突触素的表达及意义被引量：11

Expression of Syn in hippocampal CA1 region after cerebral ischemia-reperfusion in newborn rats and its significance

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摘要目的 :观察新生Wistar大鼠脑缺血再灌注后海马CA1区突触素的表达 .探讨中枢神经系统的可塑性 .方法 :应用免疫组化方法观察新生鼠脑缺血再灌注后不同时点脑组织突触素的表达 .结果 :缺血再灌注 3d突触素表达开始增高 ,7d达高峰 ,1 4d时免疫活性仍高 ,其矫正吸光度值与对照组比较有显著性差异 (P <0 .0 1 ) .结论 :新生Wistar大鼠脑神经细胞损伤后具有修复的可塑性 ,其时间持续至缺血再灌注后 1 4d . AIM: To observe synaptophysin(Syp)expression in hippocampal CA1 region of 7 day old Wistar rats after cerebral ischemia reperfusion. METHODS: Immunohistochemical method was used to measure the expression of Syp in the hippocampal CA1 region after reperfusion. RESULTS: The expression of Syp in hippocampal CA1 region in cerebral ischemia reperfusion group increased at 3 d after reperfusion and reached the highest level at 7 d. The corrected optical density(COD) value was significantly higher than that in the sham operation group ( P <0.01). CONCLUSION: Neural plasticity occurrs at 3 d and continues to 14 d after cerebral ischemia reperfusion in newborn rats. Syp is a good index indicating the regeneration of neuron and nervous axons.

作者宋文秀曹云涛刘华庆

机构地区珠海市斗门区遵义医学院第五附属医院儿科遵义医学院附属医院儿科遵义医学院附属医院病理科

出处《第四军医大学学报》 CAS 北大核心 2004年第16期1467-1469,共3页 Journal of the Fourth Military Medical University

基金贵州省卫生厅资助项目 (D 1 4 3) 贵州省省教育厅立项

关键词脑缺血突触膜糖蛋白海马CA1区大鼠 Wistar 动物新生 cerebral ischemia synaptophysin hippocampal CA1 region rats, Wistar, animals, newborn

分类号 R72 [医药卫生—儿科]

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