脑内腺苷介导白介素-1β引起的大鼠的行为性抑郁

BRAIN ADENOSINE MEDIATES INTERLEUKIN-1β-INDUCED BEHAVIORAL DEPRESSION IN RATS

目的 :研究腺苷在白细胞介素 - 1诱导的大鼠行为性抑郁中的作用。方法 :应用Porsolt游泳试验观察大鼠脑室注射白介素 - 1β引起的行为性抑郁 ,通过注射非特异性腺苷受体拮抗剂咖啡因和特异性A1和A2腺苷受体拮抗剂 ,确定脑内腺苷在白细胞介素 - 1β引起的大鼠行为性抑郁中的作用以及介导这种作用的受体。结果 :脑内注射白细胞介素 - 1β(8- 32ng/kg ,icv)可导致大鼠在Porsolt游泳试验中漂浮时间明显地延长 ,非特异性腺苷受体拮抗剂咖啡因 (7mg/kg ,ip)和特异性A2a腺苷受体拮抗剂 (1mg/kg ,ip)预处理能够缩短漂浮时间的延长。结论 :脑内注射白细胞介素 - 1β可引起大鼠的行为性抑郁 ,脑内腺苷通过A2a受体介导白细胞介素 -

Central interleukin 1 plays important roles in mediating the neural, endocrine and behavioral responses to various stressors. The aim of this study is to investigate the effect of adenosine in interleukin 1β induced behavioral depression in rats. Methods: Porsolt swim test was used for the measurement of behavioral depression after injection of interleukin 1β(8～32ng/kg, icv) and nonspecific adenosine receptor antagonist caffeine and specific adenosine receptor antagonist (A1 and A2) was used to determine the effect of adenosine in interleukin 1β induced behavioral depression. Results: Injection of interleukine 1β(8～32ng/kg, icv) induced increase of floating time in Porsolt swim test. Pretreatment with caffeine and A2a adenosine receptor antagonist blocked interleukine 1β induced increase of floating time. Conclusion: Intracerebroventricular injection of interleukin 1β induced behavioral depression in rats, which could be blocked by A2a adenosine receptor antagonist.