摘要
DNA微集阵列已广泛用于DNA测序、药物分析、基因表达等研究领域。在各种介质表面有效地固定DNA已成为该技术发展的瓶颈之一。本文对当前一些主要介质材料和寡核苷酸的固定过程进行综述。
DNA microarray has been applied to DNA sequencing,pharmaceuticals analysis,gene expression and so on. One of the key technologies is immobilizing DNA effeciently on modified surface. The main of support surfaces and the immobilization of DNA or Oligonucleotide are introduced in this article.
出处
《国外医学（生物医学工程分册）》
2004年第4期203-206,共4页
Foreign Medical Sciences(Biomedical Engineering Fascicle)
基金
国家自然科学基金资助项目(39880032)
广州市重点科技攻关项目(99-Z-022-01)
关键词
寡核苷酸固定
DNA微集阵列
介质材料
表面化学
immobilizing Oligonucleotide
DNA microarray
support material
surface chemistry
