噪声适应性暴露对人体血清中抗氧化酶活性的影响

Changes of serum antioxidant enzyme activities after sound conditioning

目的 观察在适应性噪声暴露过程中血清抗氧化酶活性的变化。方法 将新进厂工人随机分为适应组和对照组。适应组先在实验室内经适应性暴露后与对照组接触车间强噪声。测定外周血血清超氧化物歧化酶、过氧化氢酶和谷胱甘肽 -过氧化物酶的含量。结果 在预暴露于适应性噪声 10d的过程中 ,适应组血清抗氧化酶活性表现出增高的趋势。在暴露于车间强噪声 13周过程中 ,两组对象的酶活性均表现出先升高后降低的趋势 ,且适应组酶活性明显高于对照组。结论 预先反复暴露于中等强度的噪声可以增强工人血清抗氧化酶的活性 ,从而减轻噪声对听力的损伤。

Objective To evaluate if antioxidant processes may play a role in sound conditioning. Methods New young workers were randomly distributed to the conditioning group and the control group. Subjects in conditioning group were exposed to conditioning noise, and then to intense noise in a workshop with the control group. The activities of superoxide dismutase, catalase and glutathione peroxidase in serum were analyzed. Results After the 10 days' exposure to conditioning noise, the conditioning group showed an up trend in the serum antioxidant enzyme activities. Then after the exposure to intense noise for 13 weeks in workshop, the enzyme activities of both groups showed an up and then down trend, activities of conditioning group are higher than the control group. The enzyme activities showed significant difference between the conditioning group and the control group. Conclusion Repeated exposure to moderate noise increase the serum antioxidant enzyme activities of human, and the antioxidant processes may play a role in sound conditioning.