期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

POU1F1基因结构特征及其与遗传性疾病的相关性研究 被引量：1

Study on Structural Features of POU1F1 Gene and Its Relation with Genetic Diseases
下载PDF
导出
摘要 POU1F1基因是POU基因家族的成员之一,在胚胎分化和生长激素、催乳素、促甲状腺素细胞系的发育中发挥着重要作用。POU1F1基因的突变可以导致垂体的发育不全,并阻碍GH、PRL、TSHβ基因的正常分泌。文中对POU1F1基因的结构特征、功能作用进行了综述,并对不同物种的POU1F1蛋白POUHD、POUSD的氨基酸序列以及核苷酸编码序列的同源性进行了比较。 POU1F1 gene belongs to the family of POU gene. It plays a critical role in the embryonic differentiation and growth of the somatotropic, lactotropic, and thyrotropic cell lineages. It also has an important effect on the growth of pituitary and the expression of GH?PRL?TSHβ gene. In this paper, we discussed the structural features of POU1F1 gene, the function of POU1F1 gene and homologous comparison of amino acid sequence and nucleotide sequence of POU_(HD) and POU_(SD) among human, mouse, cow and pig POU1F1.
作者 滕勇 杨海明 经荣斌
机构地区 扬州大学动物科学系江苏省动物遗传育种重点实验室
出处 《吉林农业大学学报》 CAS CSCD 北大核心 2004年第3期334-338,共5页 Journal of Jilin Agricultural University
基金 江苏省"十五"科技攻关项目(BE2001364)
关键词 垂体转录因子 基因 遗传性疾病 相关性 POU1F1 gene genetic diseases correlation
分类号 Q754 [生物学—分子生物学]
  • 相关文献

参考文献26

  • 1TuggleCK,TrennkleA. Control of growth hormone synthesis [J] .Domestic Animal Endocrinol, 1996,13:1-33.
  • 2Voss J W, Roasnfeld M G. Anterior pituitary development: short tales from dwarf mice[J]. Cell, 70: 527-530.
  • 3Jacobson E M, Ii P, Leeon-Rio M G. Stmcture of Pit-1 POU domain bound to DNA as a dimmer: Unexpected arrangement and flexibility[J]. Genes Dev, 1997, 11: 198-212.
  • 4Stancekova K, Vasicek D, Peskovicova D, et al.Effect of genetic variability of the porcine pituitary-specific transcription factor (PIT1) on carcass traits in pigs[J]. Animal-Geneties , 1999, 30 (4):313-315.
  • 5Yu-T P , Rothschild M F, Tuggle C K .A Mspl restriction fragment length polymorphisp at the swine PIT-1 locus [J]. Journal of Animal Science, 1993, 71: 8, 2275.
  • 6Ohta K, Nobukuni Y.Mutation in the PIT-1 gene in children with combined pituitary hormone deficiency[J]. Biochem Biophys Res Conmun, 1992, 189(2): 851-855.
  • 7Li S, Grenshaw E. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene PIT-1[J]. Nature, 1990, 347(6293):528-533.
  • 8Yu T P, Sun H S, WShls S, et al. Cloning of the full length pig PIT-1(POU1F1) cDNA and a novel alternative PIT-1 transcript,and functional studies of their enceded proteins[J] .Animal Biotechology, 2001, 12(1): 1-19.
  • 9Huang C C, Herr W. Differential control of transcription by homologous homeodomain coregulators[J]. Mol Cell Biol, 1996, 16(6):2967-2976.
  • 10Anderson B, Rosonfeld M G. Pit-1 deternines cell types during development of the anterior pituitary gland [J]. A model for transcription Biol Chem, 1994, 269(47): 29335-29338.

同被引文献11

  • 1刘波,陈宏,蓝贤勇,雷初朝,张志清,张润锋.秦川牛及其杂种牛POU1F1基因多态与生长性能相关性[J].中国农业科学,2005,38(12):2520-2525. 被引量：31
  • 2MoodyD.EorppD,BarendseW.RestrictionfragmentlengthpolymorphisminamplificationproductsofthebovinePIT-1geneandassignmentofPIT-1tobovinechromosome[J].AnimalGenetic,1995,26:45-47.
  • 3W o o l l a r d J , T u g g l e C K a t a l ,LocalizationofPOU1F1tobovine,ovine,andcaprine1q21-22[J].JournalofAnimalScience,2000,78:242-243.
  • 4PrusinerSB.PrionBiologyandDiseaseColdSpringHarborlaboratoryPress[J].ColdSpringHarbor,NewYork,1999.
  • 5Q.Zhao,M.E.Davis,etal,AssociationofpolymorphismsinthePit-1genewithgrowthandcarcasstraitsinAngusbeefcattle[J].JournalofAnimalScience,2004,82:2 229-2 233.
  • 6NeiMRoychoudhurgAK.Samplingvarianceofhet-erozygosityandgeneticdistance[J].Genetics,1974,76:379-390.
  • 7Dy b u sA,Kmi e cM, S o b e k Z , P i e t r z y kW,WisniewskiB.Associationsbetweenpolmorphismsofgrowthhormonereleasinghormone(GHRH)a n d p i t u i t a r y t r a n s c r i p t i o n f a c t o r 1 ( P I T 1 ) g en e s a n d p r o d u c t i o n t r a o t s o fLimo u s i n e c a t t l e [J] .ArchTierzDummerstorf,2003,46(6):527-534.
  • 8ZwierzchowskiL,KizyzewskiJ,StrzalkowskaN,SiadkowskaE,RyniewiczZ.Effectofpolymorphismofgrowthhorwthhormone(GH),Pit-1,andleptin(LEP)genes,cow’sage,lactationstageandsomaticcellcountonmilkyieldandcompositionofPolishBlack-and-Whitecows[J].AnimalSciencePapersandReports,2002,20(4):213-227.
  • 9RenavilleR,GenglerN,VrechE,PrandiA,MassartS,CorradiniC,BertozziC,MortiauxF,BurnyA,PortetelleD.Pit-1genepolymorphism,milkyield,conformationtraitsforItalianHolsteinFriesianbull[J].DairySci,1997,80:3 431-3 438.
  • 10VaimanD,MecierD,Moazami-Goudarzik,EggenaA,CiampoliniR,LepingleA,VelamalaR,KaukinenJ,VarviosL,MartinP,LevezielH,GuerinG.Asetof99cattlemicrosatellitescharacterizationsyntenymappingandpolymorphism[J].MammalianGenome,1994,(5):288-297.

引证文献1

二级引证文献2

吉林农业大学学报
2004年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部