多潘立酮联合多塞平治疗功能性消化不良的疗效观察

Domperidone combined with doxepin in treatment of functional dyspepsia

目的 :探讨多潘立酮联合多塞平治疗功能性消化不良 (FD)的疗效。方法 :1 2 0例FD患者随机分为两组 ,治疗组予多潘立酮 1 0mg ,每天 3次口服 ,多塞平 5 0mg ,每晚口服。对照组予以多潘立酮 1 0mg ,每天 3次口服。疗程均为 4周。治疗前及4周后对患者腹胀、上腹部不适、早饱、烧灼感、食欲不振、嗳气 6个主要症状进行评分 ,计算疗效指数。结果 :治疗前治疗组和对照组症状总积分差异无显著性 (P >0 .0 5 )。治疗 4周后 ,治疗组症状积分和对照组症状积分较治疗前均明显降低 (P <0 .0 1 ) ,且前者比后者积分降低更显著 (P <0 .0 1 ) ,治疗组总有效率明显高于对照组 (P <0 .0 1 )。结论

Objective:To investigate the effect of domperidone combined with doxepin on functional dyspepsia.Methods:One hundred and twenty patients with functional dyspepsia were randomly divided into 2 groups.Domperidone 10 mg was given 3 times per day and doxepin 50 mg per night to the therapeutic group,and domperidone 10 mg 3 times per day to the control group for 4 weeks.The symptom scores were measured before and 4 weeks after treatment.The effective index was calculated 4 weeks after the treatment.Results:The difference between the mean total symptom scores of the therapeutic group and control group before treatment was not significant( P >0.05).The total symptom scores of the two groups decreased significantly 4 weeks later,and the difference was significant in patients receiving domperidone combined with doxepin( P <0.01).The effective rate of medical group was significantly higher than that of the control group( P <0.01).Conclusions:Domperidone combined with doxepin is significantly effective in the treatment of functional dyspepsia.