1562例六项乙型肝炎血清标志物的检测及结果分析

Analysis of six serological markers of HBV in 1 562 cases

目的 :探讨人群中乙型肝炎病毒 (HBV)的感染情况和六项乙型肝炎血清标志物的模式特征。方法 :用酶联免疫吸附测定 (ELISA)检测 1 5 6 2例非肝炎病区及门诊患者和门诊健康体检者血清HBV病毒表面抗原 (HBsAg)及其抗体 (HBsAb)、e抗原 (HBeAg)及其抗体 (HBeAb)、核心抗体IgG(HBcAb IgG)和HBcAb IgM六项HBV血清标志物 (HBVM )。 结果 :837例为全阴性 ,占总数 5 3.6 % ;72 5例为HBVM六项中有一项或一项以上为阳性 ,总阳性率为 4 6 .4 % ;模式共有 1 8种 ,分为感染期模式组和恢复期模式组 ,感染期模式组以“1 4 5”和“1 35”模式为主 ,恢复期模式组以“2”模式为主。结论 :虽然人们已重视对乙型肝炎的免疫预防 ,但乙肝的总感染率仍较高 ;HBVM六项的血清模式较为复杂 ,了解这些模式特征 ,可以帮助我们提高ELISA法对HBV检测的准确性 。

Objective:To study the infection of HBV and the different patterns of six serological markers in population.Methods:HBsAg,anti HBs,HBeAg,anti HBe,anti HBc IgG and anti HBc IgM in the serum samples from 1 562 non hepatictis patients detected by ELISA.Results:The results were negative in 837 cases,accounting for 53.6% of the total cases and the results were positive,in 725 cases,accounting for 46.4% of the total cases.There were 18 different patterns in all,which could be divided into two groups:infection pattern group and recovery pattern group.The pattern “145” and “135” were predomintant in the infection pattern group and the pattern “2” was prodomintant in the recovery pattern group.Conclusions:Although people have realized the importance of HBV immunization,the rate of HBV infection is still high in population.Having understood these patterns of serological markers of HBV,we can test the infection status of HBV more accurate by ELISA.