子宫内膜异位症并不孕患者腹腔液及外周血中细胞因子的变化

Interleukin variation in peritoneal fluid and serum of patients with endometriosis-related infertility

目的:通过检测子宫内膜异位症穴内异症雪并不孕患者腹腔液及外周血中白细胞介素鄄1α、2、6及肿瘤坏死因子α(TNF鄄α)的变化,探讨内异症致不孕的免疫机理。方法:采用酶联免疫吸附试验(ELISA),检测30例内异症并不孕患者及15例非内异症患者(对照组)腹腔液及外周血中白细胞介素鄄1α、2、6及TNF鄄α的含量,并分析细胞因子水平与AFS分期的关系。结果:内异症不孕组腹腔液及外周血中白细胞介素鄄1α、2、6及TNF鄄α水平均高于对照组(P<0.05),内异症组腹腔液中细胞因子的含量高于外周血,并与内异症的严重程度呈正相关。结论:内异症患者细胞免疫参与了不孕发生的病理生理过程熏白细胞介素鄄1α、2、6及TNF鄄α可能是导致内异症患者不孕的重要免疫学因素。

Objective: To investigate the variation of interleukin in peritoneal fluid and serum of patients with endometriosis(EM)-related infertility. Methods: The levels of IL-1y (ELISA). Results: The levels of IL-1Significant parallel relationship was found between the stages of endometriosis and the levels of IL-1Conclusion: It is likely that elevation of serum and peritoneal fluid cytokines levels may play a role in the pathogenesis of infertility associated with EM.