树突状细胞、自然杀伤细胞和粘附分子在银屑病发病中的作用

Dendritic Cells, Natural Killer Cells and Adhesion Molecules in Psoriasis

目的 研究树突状细胞、自然杀伤细胞 (NK细胞 )和粘附分子在银屑病发病中的作用。方法 采用免疫组化方法检测治疗前后银屑病皮损区人类白细胞抗原 - DR(HL A- DR)、CD1a、CD16、CD5 7、肿瘤坏死因子 - α(TNF- α)、细胞间粘附分子 - 1(ICAM- 1)的表达。结果 银屑病进行期和静止期皮损区 HL A- DR、CD1a、CD16、CD5 7、TNF- α及 ICAM- 1阳性表达无显著性差异 (P>0 .0 5 ) ;治疗后消退期皮损组织病理改善 ,各标记阳性表达明显减少甚至消失 ,经 Wilcoxon秩和检验有统计学差异 (P<0 .0 5 )。结论 树突状细胞。

Objective To study the role of the dendritic cells, natural killer cells and adhesion molecules play in the pathogenesis of psoriasis. Methods The expression levels of human leukocyte antigen(HLA)-DR, CD1a, CD16, CD57, tumor necrosis factor(TNF)-α and intercellular adhesion molecule(ICAM)-1 were detected by immunohistochemistry in lesions of 26 patients with psoriasis before and after treatment. Results The expression of HLA-DR, CD1a, CD16, CD57, TNF-α and ICAM-1 showed no significant difference between the active phase and the static phase of psoriatic lesions (P>0.05). After treatment, the positive expression of all markers decreased evidently or even disappeared with histopathological improvement in the resolvent phase of psoriatic lesions. There were statistically significant difference by Wilcoxon rank sum test (P<0.05). Conclusion Dendritic cells, natural killer cells and adhesion molecules play an important role in the pathogenesis of psoriasis.