异丙酚对人离体妊娠子宫肌自发性收缩的影响

The Effect of Propofol on Isolated Human Pregnant Uterine Muscles

目的 观察异丙酚对人离体妊娠子宫肌自发性收缩的影响。方法 将 2 0例已建立自发性规律收缩的离体子宫肌肉条随机分为对照组和异丙酚组 ,观察不同剂量异丙酚对离体子宫肌自发性收缩的影响。结果 异丙酚剂量为 0 .5、2μg/ m l时 ,对人离体妊娠子宫肌的自发性收缩无影响 ,当剂量为 5、10μg/ ml时可抑制子宫肌的收缩 ;随着异丙酚剂量的增加 ,抑制收缩作用加强 ,(14 0± 5 0 )μU/ m l的催产素可拮抗其抑制作用。结论 异丙酚以剂量 -依赖的方式抑制人离体妊娠子宫平滑肌的自发性规律收缩 。

Objective To investigate the effects of propofol on spontaneous contractions of isolated human pregnant myometrial smooth muscles. Methods Twenty isolated human pregnant myometrial muscle strips with rhythmic spontaneous contraction were randomly divided into two groups: control group (n=10) and propofol group (n=10). In propofol group propofol was added cumulatively. The changes of uterine contraction were monitored. Results Propofol at concentration of 0.5 μg/ml and 2 μg/ml had no effect on the spontaneous contraction of isolated human pregnant uterine muscles; propofol at concentration of 5 μg/ml and 10 μg/ml could significantly reduce the spontaneous contraction of isolated human pregnant uterine muscles; the higher the concentration was, the more would be the reduction. The effect could be blocked by oxytocin (140±50) μU/ml. Conclusion Propofol could significantly reduce the spontaneous rhythmic contractions of isolated human pregnant myometrial smooth muscles in concentration-dependent manner. Oxytocin could antagonize the action.