冠心病患者血清氧化型低密度脂蛋白及血液抗氧化状态分析

Study on Serum Oxidized Low Density Lipoprotein and Anti-oxidized Competence in Patient with Coronary Heart Disease

目的 分析冠心病患者血清氧化型低密度脂蛋白及血液抗氧化状态 ,探讨氧化型低密度脂蛋白及血液抗氧化状态与冠心病的关系。方法 收集 5 0例经临床确诊的冠心病患者及 5 0例无心血管疾病、糖尿病及肾病健康人群的空腹血清。进行氧化型低密度脂蛋白、过氧化脂质、血液抗氧化状态及常规血脂 (包括甘油三酯、胆固醇、高密度脂蛋白、低密度脂蛋白、载脂蛋白 A1 和 B1 0 0 、脂蛋白 a)分析。结果 冠心病组和对照组比较 ,两组的甘油三酯、胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇及载脂蛋白 B1 0 0 无差异 (P>0 .0 5 ) ,冠心病患者载脂蛋白A1 明显低于对照组 (P<0 .0 5 ) ,脂蛋白 a明显高于对照组 (P<0 .0 5 ) ;冠心病组血清过氧化脂质及氧化型低密度脂蛋白明显高于对照组 (P<0 .0 5 ) ;冠心病组一氧化氮含量和对照组无差异 ,谷胱甘肽及总抗氧化能力明显低于对照组 (P<0 .0 1)。结论 和传统的血脂分析比较 ,血清氧化型低密度脂蛋白及血液抗氧化状态分析为冠心病患者的诊断、治疗及预后评估提供更好的帮助 。

Objective To analyze the serum oxidized low density lipoprotein (OX-LDL) and anti-oxidized competence in patients with coronary heart disease,and to explore the correlation between OX-LDL and atherosclerosis(AS).Methods The samples of fasting blood-serum were collected from 50 patients with coronary heart disease(CHD) and 50 normal controls with no cardiovascular disease, diabetes mellitus and nephrosis. The levels of triglyceride(TG), cholesterol(Chol),high density lipoprotein cholesterol(HDL-C),low density lipoprotein-cholesterol(LDL-C), apoproteinA 1(Apo A 1)?apoproteinB 100(Apo B 100),lipoprotein a(Lpa),OX-LDL,lipid oxidation(LPO) and anti-oxidized competence(AOC) were detected. Results The levels of TG?Chol?HDL-C?LDL-C?Apo B 100 and NO were no difference between the patient with CHD and the normal controls (P>0.05).Lpa,OX-LDL and LPO were significantly higher than those of controls(P<0.05). ApoA 1 and AOC were significantly lower than those of controls (P<0.01).Conclusion There were no differences in respect to TG,Chol,HDL,LDL,Apo B 100 between the CHD patients and normals, but OX-LDL was significantly higher than that of controls (P<0.05) and AOC was significantly lower than that of controls. These data suggest that OX-LDL and AOC promise to find applications as more sensitive and valid markers for evaluating CHD.