环丙沙星序贯疗法预防妇科术后感染的疗效和成本-效果分析

<title>ficacy and the Cost-effectiveness analysis of Sequential Therapy of Ciprofloxacin in Precaution of Infections After Gynecological Operation

目的评价环丙沙星序贯疗法预防妇科术后感染的临床疗效和经济效果.方法411例妇科术后患者随机分为2组,序贯组(A组)205例:采用环丙沙星400mg,iv gtt,qd,连用2d后改用环丙沙星片剂500mg,po,Bid,连用3～4d;对照组(B组)206例:采用环丙沙星400mg,iv gtt,qd,连用4～5d,分别进行疗效及成本效果分析.结果A、B两组手术切口的甲级愈合率分别为96.1%和98.5%,两组术后体温变化及不良反应无统计学差异;A组的成本效果比低于B组.结论两组具有相似的临床疗效(P＞0.05),但序贯疗法与单纯静脉输注治疗相比,显著降低了总医疗费用,具有药物经济学意义.

<abstract>jective To evaluate efficacy and the cost-effectiveness of sequential therapy of ciprofloxacin in precaution of infections after gynecological operation. Methods 411 patients after gynecological operation were randomly divided into 2 groups. In the sequential therapy group(group A) there were 205 patients who were treated with ciprofloxacin iv drip in a regimen of 400mg, qd, for 2d, then with oral tablet ciprofloxacin in dose of 500mg, bid, for 3~4d in sequence; and in the contral group(group B) there were 206 patients who were treated with single ciprofloxacin iv drip in a regimen of 400mg, qd, for 4~5d. Efficacy and the cost-effectiveness in 2 groups were conducted respectively. Results The first healing rates of incisions in group A and grounp B were 96. 1% and 98. 5% respectively. The changes of temperature and the ADRs are no statistical difference between 2 groups. The costeffectiveness ratio of group A was lower than that of group B. Conclusion Similar therapeutic effect was obtained in both groups, but the total medical expenditure was significantly reduced in sequential therapy group with pharmaco-economic significance.