阿奇霉素β-环糊精包合物制备工艺的研究

<title>udy on the Preparative Technique of AM-β-CD Inclusion Complex

目的探讨饱和水溶液法制备阿奇霉素-β-环糊精包合物的最佳制备工艺研究。方法采用正交设计方法优化制备工艺。结果 优选出的最佳制备工艺为β-环糊精:阿奇霉素(摩尔比)为1:1,包合温度为40℃,搅拌时间为3h。经红外光谱法鉴定,证明阿奇霉素-β-环糊精包合物已形成。结论 阿奇霉素与β-环糊精能形成包合物,按此工艺条件制备包合物,产品的含药量达19.67±0.31％,包合物可提高阿奇霉素的溶解度。

<abstract>jective To study the optimal technique of preparing azithromycin -β-cyclodextrin (β-CD) inclusion complex by saturated aqueous solution. Methods Orthogonal design method was employed to optimize the technique of preparation. Results The best conditions of preparation are described as following: the molar ratio of AM to β-CD in the inclusion complex should be 1:1; the temperature should be 40℃ and the time of stirring should be 4 hours. It was identified by IR spectrum that azithromycin and β-cyclodextrin had formed an inclusion compound. Conclusion The content of azithromycin in the inclusion complex preparing by this optimal technique was (19. 67±0. 31)%, The solubility of. azithromycin was increased when the drug was included by β-cyclodextrin.