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抑癌基因甲基化与胃癌研究进展

Regulation of tumor suppressor gene methylation in human gastric cancer
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摘要 DNA甲基化是基因表达调控的一种方式 ,抑癌基因启动子高甲基化可以使其表达受抑 ,这与肿瘤的发生关系密切。胃癌的发生是由多因素多基因多阶段异常累计的结果 ,其中抑癌基因甲基化与胃癌的发生具有重要的关系。 DNA methylation is one of the regulators on the expression of genes,and the expression of genes can be ”silenced” by hypermethylation of the tumor suppressor genes,which is in close relationship with carcinogenesis.Gastric cancer is caused by multiple factors and multiple genes alteration and prolonged interaction.among them ,There is considerable relation between the hypermethylation of the tumor suppressor genes and the gastric carcinogenesis.
作者 林奇 周士福
机构地区 无锡市第四人民医院肿瘤外科
出处 《中国癌症杂志》 CAS CSCD 2004年第4期387-390,共4页 China Oncology
关键词 胃肿瘤 抑癌基因 DNA甲基化 gastric neoplasm tumor suppressor gene DNA methylation
分类号 R735.2 [医药卫生—肿瘤]
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参考文献26

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中国癌症杂志
2004年 第4期

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