1Tokunaga T, Yamamoto H. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I .Isolation, physicochemical characterization, and antitumor activity[J]. J Natl Cancer Inst, 1984, 72(4) :955 - 962.
2Krieg AM, Yi AK, Matson S, et al. CpG motfs in bacterial DNA trigger direct B-cell activation[J]. Nature, 1995,347(6522) :546 - 549.
3Sparwasser T, Koch ES, Vabulas RM, et al. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells[J]. Eur J Immunol, 1998, 28(6):2045-2054.
4Yi AK, Krieg AM. CpG DNA rescue from anti-IgM-induced WEHI-231 B lymphoma apoptosis via modulation of I kappa B alpha and I kappa B beta and sustained activation of nuclear factor-kappa B/c-Rel[J]. J Immunol, 1998, 160 (3): 1240 - 1245.
5Wagner M, Poeck H, Jahrsdoerfer B, et al. IL-12p70-dependent Th1 induction by human B cells requires combined activation with CD40 ligand and CpG DNA [J]. J Immunol, 2004, 172(2) :954 - 963.
6Gould MP, Greene JA, Bhoj V, et al. Distinct modulatory effects of LPS and CpG on IL-18-dependent IFN-gamma synthesis[J]. J Immunol, 2004, 172(3): 1754- 1762.
7Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response[J]. Nature, 2000, 406(6797): 782 - 787.
8Hemmi H, Takeuchi O. A Toll-like receptor recognizes bacterial DNA[J]. Nature, 2000, 408(6813) :740 - 745.
9Latz E, Schoenemeyer A, Visintin A, et al. TLR9 signals after translocating from the ER to CpG DNA in the lysosome[J]. Nat Immunol, 2004, 5(2): 190 - 198.
10Lefeber DJ, Benaissa-Trouw B. Th1-directing adjuvants increase the immunogenicity of oligosaccharide-protein conjugate vaccines related to Streptococcus pneumoniae type 3[J]. Infect Immun, 2003, 71(12):6915-6920.