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儿童生长发育对药物作用的影响及意义 被引量：6

Effects and significance of growth and development on drug metabolism in infants and children
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摘要 儿童用药不同于成人 ,随着年龄增长身体的发育会影响药物的吸收、分布、代谢及清除等许多方面 ,从而影响药物的药代动力学。儿童的用药量及用药间隔随年龄增长而有所变化 ,临床上儿童用药应当制订与年龄相适应的最佳方案 ,而不是简单的按体重或年龄给药。 Infants and children are far from adults in terms of medications. The growth and developmental changes profoundly affect the absorption, distribution and metabolism of drugs and the response to medications. The dosage and interval of drugs change along with growth and development, so it is needed those age-dependent adjustments in infants and children.
作者 鞠瑞秀 王慎田
机构地区 潍坊医学院附属青州医院药剂科
出处 《中国临床药理学与治疗学》 CAS CSCD 2004年第8期859-862,共4页 Chinese Journal of Clinical Pharmacology and Therapeutics
关键词 儿童 生长发育 药代动力学 药物代谢 children growth and development drug metabolism pharmacodynamics
分类号 R969.1 [医药卫生—药理学]
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参考文献20

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同被引文献48

  • 1抗菌药物临床应用管理办法[J].中国医学前沿杂志（电子版）,2013,5(1):9-14. 被引量：17
  • 2霍玉瑛.老年人的合理用药[J].山西医药杂志,2004,33(9):768-769. 被引量：3
  • 3Kearns GL.Impact of developmental pharmacology on pediatric study design:overcoming the challenges.J Allergy Clin Immunol,2000,106:S128-138.
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  • 6马成林,郭哲,韩秀萍,屈年贺.药物所致重症多形红斑和中毒性表皮坏死松解症的临床研究[J].临床皮肤科杂志,1997,26(2):95-96. 被引量：16
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  • 8Wallemacq, Pierre E, Verbeeck, Roger K. Comparative Clinical Pharmacokinetics of Tacrolimus in Paediatric and Adult Patients. Clinical Pharmacokinetics[J] ,2001,40(4) : 283 -295.
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  • 10张丽.儿童药理学与药物治疗学[M].北京医科大学出版社,2002:186-187.

引证文献6

二级引证文献20

中国临床药理学与治疗学
2004年 第8期

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