氯胺酮对腹腔感染脓毒症小鼠生存率的影响

Effects of ketamine on cumulative survival in septic mice induced by cecal ligation and puncture

目的 :探讨早期使用氯胺酮是否延迟盲肠结扎穿孔 (CLP)所致脓毒症小鼠的死亡时间。方法 :6 0只CLP小鼠 ,分别于术后 1、6h腹腔注射氯胺酮0、3、6、12mg·10 0g-1,观察小鼠死亡情况并比较累计生存率。结果 :氯胺酮延长CLP小鼠死亡时间 (P<0 .0 5 ) ;氯胺酮 6mg·10 0g-1组小鼠生存时间明显长于 3mg·10 0g-1组和 12mg·10 0g-1组 (P <0 .0 5 )。结论 :氯胺酮延迟CLP小鼠死亡时间 ,并呈现剂量依赖性。

AIM: To investigate the dose-related effects of ketamine on cumulative survival in mice models of polymicrobial sepsis induced by cecal ligation and puncture (CLP). METHODS: Mice with CLP were divided randomly into four groups, received ketamine injection intraperitoneally of 0, 3, 6, and 12 mg·100 g -1, respectively, at 1 and 6 h after CLP. The survival rate was observed in each group. RESULTS: No change in mortality was observed after 72 hours among four groups. Ketamine administration was associated with significant improvement of the survival of mice with CLP (P< 0.05), especially in 6 mg·100 g -1 group (P< 0.05). CONCLUSION: Ketamine administration dose-independently delays lethality from sepsis in mice with CLP.