宫颈癌危险因素病例对照研究

Case-control study on risk factors of cervical cancer

目的 探讨宫颈癌高发区的相关危险因素。方法 采用以住院患者为基础的病例对照研究方法 ,对 12 9名经病理确诊的宫颈癌患者和 14 3例非肿瘤病人对照进行有关月经、婚育史、性行为与避孕史、个人卫生习惯等因素的调查。结果 在单因素分析的基础上进行多元Logistic回归分析 ,最终引入回归方程的变量为家庭经济收入、首次性交年龄、洗澡设施、妇科病史、产次和绝经 ,而结婚年龄、首次发生性行为和孕育年龄、孕产次等生殖因素 ,则与宫颈癌发生的危险性呈剂量 -反应关系。结论 经济收入低、首次发生性行为的年龄小、既往有妇科病史、孕产次多可增加宫颈癌发生的危险性 ,特别值得注意的是洗澡和清洗阴部少等不洁卫生习惯可能是导致当地该病高发的原因之一 ,绝经后妇女宫颈癌发生的危险性较低。

Objective To investigate the risk factors of cervical cancer in high incidence areas.Methods A hospital based case-control study was conducted.129 cases with cervical cancer by pathological diagnoses and 143 patients with non-neoplasm as controls were interviewed using a questionnaire,including baseline information,menstrual,marital and pregnancy histories,sexual behavior,contraception history and personal health habits,etc.Results Based on monovariate analysis results,multivariate non-conditional logistic analysis was used.Personal income,age at first intercourse,bath service,parity,menopause and history of gynecologic disease were associated with cervical cancer.Meanwhile,the marriage age,first intercourse age,pregnancy and birth age,gravidity and parity expressed the relationship of dosage-response with cervical cancer.Conclusion The relative risk of cervical cancer enhanced with decreasing age at first intercourse,number of taking bath and personal income,and with increasing number of gravidity and parity.No good health-habit was related to cervical cancer,which should be taken more attention to.The risk on occurrence of cervical cancer reduced in women with post-menopause.