肠息肉与结直肠癌发病关系队列研究

Cohort study on association between colorectal cancer and colorectal polypi

目的 研究肠息肉与结直肠癌发病之间的关系。方法 以 1989年 5月～ 1990年 4月 ,参加浙江省嘉善县大肠癌筛查的 10个乡镇 30岁及以上人口为研究队列 ,按是否具有肠息肉分为暴露组和非暴露组 ,从 1990年 5月～2 0 0 0年 1月进行随访 ,应用回顾性队列研究的方法 ,对结直肠癌发病率进行分析 ,并作相对危险度 (RR)估计。结果 暴露组和非暴露组的结直肠癌发病率具有显著性差异 (P <0 0 5 ) ,Logistic回归分析表明 ,控制年龄因素后 ,肠息肉史仅在男性结肠癌表现出有统计学意义 ,有肠息肉史者结肠癌的发病风险较无肠息肉史者高 10余倍 ,RR为 10 79,95 %可信限为 3 80 2～ 30 6 0 5。结论 肠息肉史与结肠癌的发病有关 ,肠息肉史是结肠癌的重要危险因子。

Objective In order to identify the association between colorectal cancer and colorectal polypi.Methods Based on the screening for CRC among residents aged 30 and over 30 years in 10 villages and towns of Jiashan-county in China from 1989 May to 1990 April,cohort members were followed-up for CRC from 1990 May to 1999 December.The incidence of CRC were anlyzed with different histroy of colorectal polypi,and RR estimates were given to each sex and sites by controlling age.Results There were statistical significance in different history of colorectal polypi.After controlling age,there were statistical significance only in male (RR=10 79,95%CI(3 802-30 605).Conclusion Cohort study might uncover the association between colorectal polypi and colorectal cancer.