Survivin在膀胱移行细胞癌中的表达及其临床意义

Expression and Clinical Significance of Survivin in Transitional Cell Bladder Carcinoma

目的 探讨凋亡抑制因子Survivin在膀胱移行细胞癌中表达的临床意义。方法 采用免疫组织化学(SABC)法检测 75例膀胱移行细胞癌中Survivin的表达情况 ,回顾性分析Survivin与各临床病理因素及预后之间的关系。结果 Survivin在正常膀胱粘膜上皮中不表达 ,75例膀胱癌标本中 ,35例Survivin阳性 ( 4 6 .7% ) ,Survivin阳性率在Ⅰ、Ⅱ和Ⅲ级肿瘤中分别为 2 6 .9% ( 7/ 2 6 )、4 8.5 % ( 16 / 33)和 75 .0 % ( 12 / 16 )。在Tis～T1期和T2 ～T4期肿瘤分别为 34.2 % ( 14 / 4 1)和 6 1.8% ( 2 1/ 34)。Survivin表达阳性率随着膀胱癌病理分级、临床分期的上升而逐渐升高 ,其阳性率在肿瘤的不同病理分级、临床分期和预后等方面均有显著性差异 (P <0 .0 5 )。结论 Survivin表达在膀胱癌的发生、发展中起重要作用 ,可作为膀胱癌的生物学指标。

Objective To investigate the expression of survivin and its clinical significance in human transitional cell bladder carcinoma. Methods Immunohisto-chemistry method was used to detect survivin expression in 75 cases of bladder transitional cell carcinoma The relationship between survivin expression and the clinicopathologic parameters and prognosis was retrospectively analyzed. Result Survivin expression was not detected in healthy bladder mucosa.Survivin expression was positive in 35 of 75(46.7%).The survivin expression positive rate in grade Ⅰ、Ⅱ and Ⅲ tumors was 26.9(7/20),48.5%(16/33)、75.0%(12/16) and in stage Tis～T 1 and T 2～T 4 tumors 34.2%(14/41) and 61.8% (21/34).The survivin expression positive rates were significantly higher in poorly differentiated and invasive bladder cancer.Expression of survivin was correlated well with histological grade、clinical stage and prognosis. Conclusions There was an important role of survivin expression in the development and for the progression of bladder cancer.Survivin expression could be used as a tumor marker for bladder cancer.