高住低训中EPO变化规律的研究

Study of EPO Changes and Regularity During Living High-Training Low

血清EPO(erythropoietin,促红细胞生成素)与红细胞的生成有密切关系。为确切了解EPO在高住低训中的变化规律,将14名大学生分为高住低训组和低住低训组,每组7人。高住低训组每天低压低氧(2500m模拟高度)暴露12小时;低住低训组在实验期间不进行低氧暴露。两组每天在常压常氧环境下进行一次3000m跑训练。实验为期4周。结果表明,促红细胞生成素在间断性低氧暴露初期就有升高变化,11天后出现高峰,这一高EPO水平一直维持到低压氧暴露结束。另外,对第2次低氧暴露完当天出低压氧仓即刻与常氧暴露10h后所测EPO结果的比较表明,常氧暴露后EPO呈下降趋势,说明间断性低氧暴露对EPO生成存在着慢性积累的过程。低住低训组的EPO水平一直比较平稳,说明常氧环境对EPO的分泌无明显影响。

EPO is the major regulator of RBC generation.To have a understanding of EPO changes during living high-training low,this study divided 14 college students into 2 groups with 7 in each.The groups are:1)HiLo group(living high-training low group);2)LoLo group(living low-training low group).HiLo group was exposed to low levels of air pressure and oxygen (simulated 2,500-meter altitude)for 12 hours and trained 3,000 m at sea level every day.However,LoLo only trained at sea level.This protocol lasted for 4 weeks.Study shows that after the 2nd exposure to low pressure and low oxygen,EPO showed a trend of increasing.After 11 days of exposure,there was an EPO peak.The peak remained until the end of exposure.In addition,comparing the data taken immediately after coming out of the low pressure and oxygen room and the one taken 10 hours later,the EPO showed a trend of decreasing.This indicated that the developing of EPO has a chronic accumulation at intermittent hypoxia exposure.EPO level in LoLo group is equable which shows that secrete of EPO in sea level is stable.