土茯苓酚苷类成分研究

Phenolic glycosides from rhizome of Smilax glabra

目的研究土茯苓的化学成分。方法用硅胶、大孔树脂、ODS柱色谱及HPLC方法进行分离纯化,根据理化性质和光谱数据进行结构鉴定。结果得到6个化合物,分别为2,4,6-三羟基苯乙酮-2,4-二-O-β-D-吡喃葡萄糖苷()、3,4,5-三甲氧基苯基-1-O-β-D-吡喃葡萄糖苷()、3,4,5-三甲氧基苯基-1-O-[β-D-呋喃芹糖基-(1→6)]-β-D-吡喃葡萄糖苷()、3,4-二羟基苯乙醇-3-O-β-D-吡喃葡萄糖苷()、8,8′-双二氢丁香苷元葡萄糖苷(8,8′-bisdihydrosyringeninglucoside,)、白藜芦醇-3-O-β-D-吡喃葡萄糖苷()。结论化合物为首次从天然界中分得,其余化合物为首次从土茯苓中分得。

Object To investigate the chemical constituents from the rhizome of Smilax glabra Roxb Methods The compounds were isolated by column chromatography on silica gel, Diaion HP 20, ODS, and HPLC, their structures were determined on the basis of their spectroscopic evidences Results Six compounds were identified as: 2, 4, 6 trihydroxyacetophenone 2, 4 di O β D glucopyranoside (Ⅰ), 3, 4, 5 trimethoxyphenyl 1 O β D glucopyranoside (Ⅱ), 3, 4, 5 trimethoxyphenol 1 O [β D apiofuranosyl (1→6)] β D glucopyranoside (Ⅲ), 3, 4 dihydroxyphenothyl 3 O β D glucopyranoside (Ⅳ), 8, 8′ bisdihydrosyringenin glucoside (Ⅴ), resveratrol 3 O β D glucopyranoside (Ⅵ) Conclusion Compound Ⅰ is obtained from the nature for the first time, other compounds are isolated from this plant for the first time