溃疡性结肠炎患者血浆白介素-13检测和临床价值

Clinical significance of blood plasma level of interleukin 13 in patients with ulcerative colitis

目的 探讨溃疡性结肠炎 (UC)患者血浆白介素 - 13(IL - 13)临床价值。方法 采用ELISA法检测UC患者和正常健康人血浆IL - 13浓度。结果 31例UC患者 (16 .6 5± 3.38)pg/ml和 30例健康人 (2 5 .83± 3.5 9)pg/ml血浆IL - 13浓度比较 ,差异有显著性 (P <0 .0 5 )。活动期 (2 1例 )和静止期 (10例 )UC患者血浆IL - 13浓度分别为(12 .0 3± 3.72 )pg/ml和 (18.6 7± 4 .2 2 )pg/ml,两者比较差异有显著性 (P <0 .0 5 )。轻、中、重度活动期UC血浆IL -13浓度相互比较 ,差异有显著性 (P <0 .0 5 )。UC患者血浆IL - 13和血清C -反应蛋白浓度呈负相关 (r=- 0 .5 98,P <0 .0 1)。结论 IL - 13参与UC的炎症过程 ,检测血浆IL - 13可作为判断UC患者病变严重程度和复发的指标之一。

Objective To explore clinical significance of blood plasma level of interleukin 13(IL-13) in patients with ulcerative colitis(UC).Methods The blood plasma level of IL-13 was detected by enzyme-linked immunosorbent assay(ELISA) in patients with UC.Results\ The blood plasma level of IL-13 in patients with UC(31 cases) was clear lower than that in normal people(30 cases)[(16.65±3.38) pg/ml vs (25.83±3.59) pg/ml,P<0.05].There are significant statistical differences between active UC(21 cases) and quiescent UC(10cases)[(12.03±3.72) pg/ml vs (18.67±4.22) pg/ml,P<0.05]. Comparing mild , moderate and severe UC , the blood plasma level of IL-13 was clear difference (P<0.05). The blood plasma level of IL-13 was negative correlation with serum level of C-reaction protein (r=-0.598,P<0.01).Conclusion\ IL-13 is involved in the process of inflammation in UC patients , and may act as one of index in judging UC severity and UC relapse.