甲磺酸二氢麦角碱用于脑梗死恢复期病人的临床观察

Effect of Dihydroergotamine Mesilate on Rehabilitation of Cerebral Infarction Patient

目的 评估甲磺酸二氢麦角碱对脑梗死后功能恢复的疗效。方法 采用多中心、随机对照原则。对脑梗死后 1个月病人 ,随机服用甲磺酸二氢麦角碱及肠溶阿司匹林或单服肠溶阿司匹林 ,每日各 2片 ,共 2个月 ,每月随诊 1次 ,以巴氏指数 (BI)、长谷川量表 (HDS)作为疗效评估指标。结果 10 2例最终完成 2个月随访 ,其中甲磺酸二氢麦角碱加肠溶阿司匹林组 5 3例 ,肠溶阿司匹林组 49例。巴氏指数在治疗后第 1个月、第 2个月甲磺酸二氢麦角碱加肠溶阿司匹林组均优于肠溶阿司匹林组 (P <0 .0 5 )。长谷川痴呆量表第 1个月无显著性差异 ,而治疗第 2个月优于肠溶阿司匹林组 (P <0 .0 5 )。加用甲磺酸二氢麦角碱组的不良反应发生率为7.5 % ,另一组为 4.1% ,主要表现为头痛、恶心、胃灼热 ,但并不影响继续治疗。

Objective To assess efficacy of Dihydroergotamine Mesilate on cerbral infarction patient.Methods A clinical trial was done with a method of many ceter,random contrast .Patients with cerbral infarction received randomized treatment of either Dihydroergotamine Mesilate and aspirin 2 tablets or aspirin 2 tablets daily only for 2 months .The treatment effect were assessed by using Barthel Index(BI) and Hasagawa dementia scales (HDS) every month after giving treatment.Results In this study ,only 102 cases were observed .Of them,53patients received Dihydroergotamine Mesilate and aspirin,49 patients received aspirin only. The baseline characteristics were compared between both groups.Treatment group was significantly more effective than control group by increasing BI after 1 or 2 month.Treatment group was significantly more effective than control group by increasing HDS after 2 month too .More adverse events were reported in treatment group than control group but the difference was not significant at the 5% level .All these events were headache, nausea ,and brashness which had no effect on continuous treatment.Conclusion Dihydroergotamine Mesilate can accelerate the recovery of nervous function in some degrees after stroke.