氧氟沙星不同给药方案治疗伤寒的经济学分析

Cost-Effective Analysis of Different Administration Options of Ofloxacin in Treatment of Typhoid

运用药物经济学成本—效果分析法寻找治疗伤寒的最佳方案。根据文献数据 ,对 10 4例伤寒患者 ,分别采用氧氟沙星序贯给药、连续静脉滴注以及口服给药治疗的临床效果进行成本效果分析。结果显示 ,3种治疗方法的治愈率相似 (P >0 0 5 ) ,序贯疗法和静脉疗法的完全退热时间相似 (P >0 0 5 ) ,序贯疗法和口服疗法的完全退热时间有显著差异 (P <0 0 1) ,序贯治疗组的抗菌素费用及医疗总费用低于静脉治疗组 ,高于口服治疗组。从药物经济学角度看 ,序贯疗法是 3种氧氟沙星治疗伤寒方案中的最佳方案。

Based on documentation data of 104 patients, a cost-effective analysis was used to find the best therapeutic scheme for typhoid treatment by Ofloxacin. The options of sequential administration, intravenous administration and oral administration were compared. Cure rate of the three options were similar (P>0 05) and the complete febrifugal time in sequential therapy and intravenous therapy was also similar (P>0 05). Sequential therapy had a significantly different febrifugal time from oral therapy (P<0 01). As regards antibiotics cost and total medical cost, sequential therapy was lower than intravenous therapy but higher than oral therapy. From pharmacoeconomic points of view, sequential administration of ofloxacin was the best option in the three typhoid treatment schemes.