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脂联素与2型糖尿病及其大血管并发症

Adiponectin and type Ⅱ diabetes as well as its trumk complications
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摘要 实验室和临床研究提示 ,脂联素与糖尿病大血管并发症的发生有密切的关系。脂联素具有抵抗动脉粥样硬化的作用。因此 ,作为一种仅由脂肪细胞分泌的蛋白质 ,脂联素将在糖尿病及其大血管并发症的治疗中有广泛的应用前景。 The laboratory and clinical research suggests that adiponectin has close relations with trunk complication of diabetes.Adiponectin has function of resisting the vascular sclerosis.So as a kind of protein that secreted by fat cell,adiponectin has extensive apllication prospects in treatment of diabetes and its complications.
机构地区 柳州市人民医院
出处 《华夏医学》 2004年第4期657-658,共2页 Acta Medicinae Sinica
关键词 脂联素 糖尿病 并发症 adiponectin diabetes complications
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参考文献15

  • 1[1]Saito K,Tobe T,Minoshima S,et al.Organization of the gene for gelatin-binding protein(GBP28)[J].Gene,1999,229(1-2):67-73.
  • 2[2]Nakano Y,Tobe T,Choi-Miura NH,et al.Isolation and characterization of GBP28,a novel gelatin-binding protein purified from human plasma[J].J Biochem(Tokyo),1996,120(4):803-812.
  • 3[3]Hotta K,Funahashi T,Bodkin NL,et al.Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys[J].Diabetes,2001,50(5):1126-1133.
  • 4[4]Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity[J]. Biochem Biophys Res Commun, 1999,257:79-83.
  • 5[5]Hotta K, Funahashi T, Arita Y, et al. Plasma concentrations of a novel adipose-specific protein, adiponectin, in type 2 diabetic patients[J]. Arterioscl Thromb Vase Biol,2000,20:1595-1599.
  • 6卢慧玲,王宏伟,林汉华,张木勋.血浆脂联素与2型糖尿病胰岛素抵抗关系的研究[J].临床内科杂志,2003,20(11):594-596. 被引量:9
  • 7靳立忠,刘德敏,于德民,李戈,汪玮琳,范新萍.脂联素基因Gly15Gly多态性与2型糖尿病的相关性研究[J].天津医科大学学报,2003,9(2):211-213. 被引量:11
  • 8谷卫,曾文衡,船桥通.2型糖尿病患者皮下、大网膜脂肪组织脂联素mRNA表达的定量研究[J].中华内分泌代谢杂志,2002,18(5):400-403. 被引量:30
  • 9[9]Maeda N, Takahashi M, Funahashi T, et al. PPAR-γ Ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein[J]. Diabetes.2001,50:2094-2099.
  • 10[10]Zoccali C, Mallamaci F, Tripepi G, et al. Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease[J]. J Am Soc Nephrol,2002,13:134-141.

二级参考文献19

  • 1李光伟,Step.,L.检测人群胰岛素敏感性的一项新指数[J].中华内科杂志,1993,32(10):656-660. 被引量:2125
  • 2Hara K, Boutin P, Mori Y, et al. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population[J] .Diabetes,2002, 51 : 536.
  • 3Yokota T, Oritani K, Takahashi I, et al. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the function of macrophages[J]. Blood, 2000, 96:1723.
  • 4Hotta K, Funahashi T, Arita Y, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients[J]. Arterioscler Thromb Vasc Biol, 2000, 20:1595.
  • 5Kondo H, Shimomura I, Matsukawa Y, et al. Association of adiponectin mutation with type 2 diabetes[J]. Diabetes, 2002,51 : 2325.
  • 6Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia[J]. J Clin Endocrinol Metab,2001,86:1930.
  • 7Hotta K, Funahashi T, Bodkin NL, et al. Circulation concentrations of the adipocyte protein, adipoenctin, are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys[J] . Diabetes, 2001, 50 :1126.
  • 8Maeda N, Shimomura L, Kishida K, et al. Diet-induced insulin resistance in mice lacking adiponectin/Acrp 30[J]. Nat Med,2002, 8:731.
  • 9Stumvoll M, Tschritter O, Fritsche A, et al. Association of the T - G polymorphism in adiponectin(exon2) with obesity and insulin sensitivity [J]. Diabetes, 2002, 51 : 37.
  • 10Menzaghi C, Ercolino T, Paola RD, et al. A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome[J].Diabetes, 2002, 51:2306.

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